Connect with LearnSmart Labs for Lab Manual for Human Anatomy & Physiology
4th Edition
ISBN: 9781260159233
Author: Terry Martin, Cynthia Prentice-Craver
Publisher: Mcgraw-hill Higher Education (us)
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Chapter 52, Problem 2.3A
Why might vital capacity and expiratory reserve decrease with age?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
Chapter 52 Solutions
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