CAMPBELL'S BIOLOGY MASTERING BIOLOGY
CAMPBELL'S BIOLOGY MASTERING BIOLOGY
12th Edition
ISBN: 9780135855843
Author: Urry
Publisher: PEARSON
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Chapter 52, Problem 11TYU

SCIENTIFIC INQUIRY Jens Clausen and colleagues, at the Carnegie Institution of Washington, studied how the size of yarrow plants (Achillea lmmlosa) growing on the slopes of the Sierra Nevada varied with elevation. They found that plants from low elevations were generally taller than plants from high elevations, as shown in the diagram.

Chapter 52, Problem 11TYU, SCIENTIFIC INQUIRY Jens Clausen and colleagues, at the Carnegie Institution of Washington, studied

Data from J. Clausen et al., Experimental studies on the nature of species III. Environmental responses of climatic races of Achillea, Carnegie Institution of Washington Publication No 581 (1948)

Clausen and colleagues proposed two hypo theses to explain this variation within a species: (1) ·There are genetic differences between populations of plants found at different elevations. (2) The species has developmental flexibility and can assume tall or short growth forms, depending on local abiotic factors. If you had seeds from yarrow plants found at low and high elevations, how would you test these hypotheses?

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data  (b) k, ka, B1, and AUC* for the po data  (c) k, ka, B1, and AUC* for the ip data  (d) relative bioavailability for po vs ip, Fpo/Fip  (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip    MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.
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Chapter 52 Solutions

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