CAMPBELL'S BIOLOGY MASTERING BIOLOGY
CAMPBELL'S BIOLOGY MASTERING BIOLOGY
12th Edition
ISBN: 9780135855843
Author: Urry
Publisher: PEARSON
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Chapter 51, Problem 9TYU

SCIENTIFIC INQUIRY Scientists studying scrub jays found that “helpers” often assist mated pairs of birds by gathering food for their offspring.

(A)    Propose a hypothesis to explain what advantage there might be for the helpers to engage in this behavior instead of seeking their own territories and mates.

(B)    Explain how you would test your hypothesis. If it is correct, what results would you expect your tests to yield?

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data  (b) k, ka, B1, and AUC* for the po data  (c) k, ka, B1, and AUC* for the ip data  (d) relative bioavailability for po vs ip, Fpo/Fip  (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip    MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.
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