Laboratory Manual For Human Anatomy & Physiology
4th Edition
ISBN: 9781260159363
Author: Martin, Terry R., Prentice-craver, Cynthia
Publisher: McGraw-Hill Publishing Co.
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Textbook Question
Chapter 51, Problem 2.2A
Complete the following:
a. How do your test results compare with the expected values?
b. How does your vital capacity compare with the average value for a person of your sex, age, and height?
c. What measurement in addition to vital capacity is needed before you can calculate your total lung capacity?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
List substitutions in your diet you could make to improve it based on what you know now about a balanced diet. For instance, if you like to drink soda, you might substitute skim milk or water for some of the soft drinks you consumed. List the item you wish to replace with the new item and what you hope to accomplish with that substitution. Be sure to choose foods you know that you'd enjoy and you consider more "healthful." If you feel your diet is already balanced, describe how you accomplish your balanced intake and when you began eating this way.
Chapter 51 Solutions
Laboratory Manual For Human Anatomy & Physiology
Ch. 51 - The size of the thoracic cavity is increased by...Ch. 51 - Prob. 2PLCh. 51 - Prob. 3PLCh. 51 - Prob. 4PLCh. 51 - A normal resting breathing rate is about...Ch. 51 - The contraction of the diaphragm increases the...Ch. 51 - Prob. 7PLCh. 51 - Vital capacities gradually decrease as a person...Ch. 51 - When using the lung function model, what part of...Ch. 51 - When the diaphragm contracts, the size of the...
Ch. 51 - The ribs are raised primarily by contraction of...Ch. 51 - The primary muscles that help to force out more...Ch. 51 - We inhale when the diaphragm _________.Ch. 51 - Complete the following: a. How do your test...Ch. 51 - Match the air volumes in column A with the...Ch. 51 - To determine possible obstruction of the airway, a...
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