Production of unlimited B cell receptors (BCRs), T cell receptors (TCRs) and antibodies by recombinant DNA (deoxyribonucleic acid) technology. Introduction: There are millions of diverse TCRs, BCRs and antibodies in our body. All of them are highly specific for a particular epitope. TCR consist of two α chains and two β chains whereas BCR and antibody consist of two identical heavy chains and two identical light chains. All three of them contains variable regions and constant regions. Ability to recognize a specific epitope is based on the fact that they have unique variable region for every epitope, leading to diversity in TCRs, BCRs and antibodies.

Question

Want to see the full answer?

Answer 1

Question

Chapter 51, Problem 12TYU

Summary Introduction

To review:

Production of unlimited B cell receptors (BCRs), T cell receptors (TCRs) and antibodies by recombinant DNA (deoxyribonucleic acid) technology.

Introduction:

There are millions of diverse TCRs, BCRs and antibodies in our body. All of them are highly specific for a particular epitope. TCR consist of two α chains and two β chains whereas BCR and antibody consist of two identical heavy chains and two identical light chains. All three of them contains variable regions and constant regions. Ability to recognize a specific epitope is based on the fact that they have unique variable region for every epitope, leading to diversity in TCRs, BCRs and antibodies.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

Alleles at the P locus control seed color. Plants which are pp have white seeds, white flowers and no pigment in vegetative parts. Plants which are P_ have black seeds, purple flowers and may have varying degrees of pigment on stems and leaves. Seed color can be assessed, visually, based on if the seed is white or not white A gene for mold resistance has been reported and we want to determine its inheritance and whether it is linked to P. For the purposes of this exercise, we will assume that resistance is controlled by a single locus M, and M_ plants are resistant and mm plants are susceptible. Resistance can be measured, under greenhouse conditions, 2 weeks after planting, by injecting each seedling with a spore suspension. After two weeks, the seedlings can be rated as resistant or susceptible, based on whether or not tissue is actively sporulating. For this exercise we will use seed and data from the F10 generation of a recombinant inbred population produced using single seed…

Linkage in common bean Alleles at the P locus control seed color. Plants which are pp have white seeds, white flowers and no pigment in vegetative parts. Plants which are P_ have black seeds, purple flowers and may have varying degrees of pigment on stems and leaves. Seed color can be assessed, visually, based on if the seed is white or not white A gene for mold resistance has been reported and we want to determine its inheritance and whether it is linked to P. For the purposes of this exercise, we will assume that resistance is controlled by a single locus M, and M_ plants are resistant and mm plants are susceptible. Resistance can be measured, under greenhouse conditions, 2 weeks after planting, by injecting each seedling with a spore suspension. After two weeks, the seedlings can be rated as resistant or susceptible, based on whether or not tissue is actively sporulating. For this exercise we will use seed and data from the F10 generation of a recombinant inbred population…

Alleles at the P locus control seed color. Plants which are pp have white seeds, white flowers and no pigment in vegetative parts. Plants which are P_ have black seeds, purple flowers and may have varying degrees of pigment on stems and leaves. Seed color can be assessed, visually, based on if the seed is white or not white A gene for mold resistance has been reported and we want to determine its inheritance and whether it is linked to P. For the purposes of this exercise, we will assume that resistance is controlled by a single locus M, and M_ plants are resistant and mm plants are susceptible. Resistance can be measured, under greenhouse conditions, 2 weeks after planting, by injecting each seedling with a spore suspension. After two weeks, the seedlings can be rated as resistant or susceptible, based on whether or not tissue is actively sporulating. For this exercise we will use seed and data from the F10 generation of a recombinant inbred population produced using single seed…