CONNECT ACCESS FOR BIOL 01204 <C>
CONNECT ACCESS FOR BIOL 01204 <C>
12th Edition
ISBN: 9781264443123
Author: Raven
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 50, Problem 4IQ
Summary Introduction

To describe: How the elimination of smallpox virus with the help of a vaccine was possible but not the elimination of influenza.

Introduction: The smallpox disease, caused by the variola virus, was a fatal disease common in the earlier centuries. Edward Jenner proposed the thought that cowpox infection could provide immunity against smallpox. His procedure of infecting a known harmless substance to confer immunity to a rather lethal infection is referred to as vaccination. However, several pathogens modify their surface antigens to prevent detection by the immune system.

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You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?
You decide to delete Fgf4 and Fgf8 specifically in the limb bud. Explain why you would not knock out these genes in the entire embryo instead.
You implant an FGF10-coated bead into the anterior flank of a chicken embryo, directly below the level of the wing bud. What is the phenotype of the resulting ectopic limb?  Briefly describe the expected expression domains of 1) Shh, 2) Tbx4, and 3) Tbx5 in the resulting ectopic limb bud.

Chapter 50 Solutions

CONNECT ACCESS FOR BIOL 01204 <C>

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