Chapter 5, Problem 4P

Summary Introduction

To determine: The dissociation rate, disoociation constant, and appropriate units when a protein calcineurin binds to the protein calmodin with an association rate of $\text{8}{\text{.9 ×10}}^{\text{3}}{\text{ m}}^{\text{-1}}{\text{s}}^{\text{-1}}$ and overall dissociation constant of 10 nm.

Introduction:

Dissociation constant (K_d) explains the binding of a ligand to its particular receptor. In molar concentration, dissociation constant matches with the concentration of the ligands. The smaller the K_d the more strongly bound the ligand to its receptors and high K_d indicates less affinity.