The intracellular and interstitial fluid volume of a patient if the total body water volume is 42 L, ECF volume is found to be 12.5 L, and the plasma volume of the patient is 2.7 L. Introduction: In humans, body fluid is present in different compartments forms. Body fluid in each compartment has its characteristics and functions to perform. These compartments in the body are separated by some form of physical barriers. Fluid in each of these compartments increases or decreases according to the physiological conditions of the body. Two of the main fluid compartments in the body are: Intracellular fluid (ICF) compartment; and Extracellular fluid (ECF) compartment.

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Answer 1

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Chapter 5, Problem 31RQ

a.

Summary Introduction

To determine: The intracellular and interstitial fluid volume of a patient if the total body water volume is 42 L, ECF volume is found to be 12.5 L, and the plasma volume of the patient is 2.7 L.

Introduction: In humans, body fluid is present in different compartments forms. Body fluid in each compartment has its characteristics and functions to perform. These compartments in the body are separated by some form of physical barriers. Fluid in each of these compartments increases or decreases according to the physiological conditions of the body. Two of the main fluid compartments in the body are: Intracellular fluid (ICF) compartment; and Extracellular fluid (ECF) compartment.

b.

Summary Introduction

To determine: The amount of solute present in the whole body, ECF, ICF, and plasma of the patient.

Introduction: Different body fluids contain different amount of solute particles. Based on the concentration of solute present in the fluid, a concentration gradient is set up between the fluids. This concentration gradient is responsible for the movement of water across the boundaries. The concentration of these solutes is measured in terms of the osmolarity of the fluid.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

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Answer 2

Question

Chapter 5, Problem 31RQ

a.

Summary Introduction

To determine: The intracellular and interstitial fluid volume of a patient if the total body water volume is 42 L, ECF volume is found to be 12.5 L, and the plasma volume of the patient is 2.7 L.

Introduction: In humans, body fluid is present in different compartments forms. Body fluid in each compartment has its characteristics and functions to perform. These compartments in the body are separated by some form of physical barriers. Fluid in each of these compartments increases or decreases according to the physiological conditions of the body. Two of the main fluid compartments in the body are: Intracellular fluid (ICF) compartment; and Extracellular fluid (ECF) compartment.

b.

Summary Introduction

To determine: The amount of solute present in the whole body, ECF, ICF, and plasma of the patient.

Introduction: Different body fluids contain different amount of solute particles. Based on the concentration of solute present in the fluid, a concentration gradient is set up between the fluids. This concentration gradient is responsible for the movement of water across the boundaries. The concentration of these solutes is measured in terms of the osmolarity of the fluid.

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Answer 3

Question

Chapter 5, Problem 31RQ

a.

Summary Introduction

To determine: The intracellular and interstitial fluid volume of a patient if the total body water volume is 42 L, ECF volume is found to be 12.5 L, and the plasma volume of the patient is 2.7 L.

Introduction: In humans, body fluid is present in different compartments forms. Body fluid in each compartment has its characteristics and functions to perform. These compartments in the body are separated by some form of physical barriers. Fluid in each of these compartments increases or decreases according to the physiological conditions of the body. Two of the main fluid compartments in the body are: Intracellular fluid (ICF) compartment; and Extracellular fluid (ECF) compartment.

b.

Summary Introduction

To determine: The amount of solute present in the whole body, ECF, ICF, and plasma of the patient.

Introduction: Different body fluids contain different amount of solute particles. Based on the concentration of solute present in the fluid, a concentration gradient is set up between the fluids. This concentration gradient is responsible for the movement of water across the boundaries. The concentration of these solutes is measured in terms of the osmolarity of the fluid.

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Answer 4

Question

Chapter 5, Problem 31RQ

a.

Summary Introduction

To determine: The intracellular and interstitial fluid volume of a patient if the total body water volume is 42 L, ECF volume is found to be 12.5 L, and the plasma volume of the patient is 2.7 L.

Introduction: In humans, body fluid is present in different compartments forms. Body fluid in each compartment has its characteristics and functions to perform. These compartments in the body are separated by some form of physical barriers. Fluid in each of these compartments increases or decreases according to the physiological conditions of the body. Two of the main fluid compartments in the body are: Intracellular fluid (ICF) compartment; and Extracellular fluid (ECF) compartment.

b.

Summary Introduction

To determine: The amount of solute present in the whole body, ECF, ICF, and plasma of the patient.

Introduction: Different body fluids contain different amount of solute particles. Based on the concentration of solute present in the fluid, a concentration gradient is set up between the fluids. This concentration gradient is responsible for the movement of water across the boundaries. The concentration of these solutes is measured in terms of the osmolarity of the fluid.

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Answer 5

Chapter 5, Problem 31RQ

a.

Summary Introduction

To determine: The intracellular and interstitial fluid volume of a patient if the total body water volume is 42 L, ECF volume is found to be 12.5 L, and the plasma volume of the patient is 2.7 L.

Introduction: In humans, body fluid is present in different compartments forms. Body fluid in each compartment has its characteristics and functions to perform. These compartments in the body are separated by some form of physical barriers. Fluid in each of these compartments increases or decreases according to the physiological conditions of the body. Two of the main fluid compartments in the body are: Intracellular fluid (ICF) compartment; and Extracellular fluid (ECF) compartment.

b.

Summary Introduction

To determine: The amount of solute present in the whole body, ECF, ICF, and plasma of the patient.

Introduction: Different body fluids contain different amount of solute particles. Based on the concentration of solute present in the fluid, a concentration gradient is set up between the fluids. This concentration gradient is responsible for the movement of water across the boundaries. The concentration of these solutes is measured in terms of the osmolarity of the fluid.

Answer 6

Chapter 5, Problem 31RQ

a.

Summary Introduction

To determine: The intracellular and interstitial fluid volume of a patient if the total body water volume is 42 L, ECF volume is found to be 12.5 L, and the plasma volume of the patient is 2.7 L.

Introduction: In humans, body fluid is present in different compartments forms. Body fluid in each compartment has its characteristics and functions to perform. These compartments in the body are separated by some form of physical barriers. Fluid in each of these compartments increases or decreases according to the physiological conditions of the body. Two of the main fluid compartments in the body are: Intracellular fluid (ICF) compartment; and Extracellular fluid (ECF) compartment.

Answer 7

Chapter 5, Problem 31RQ

a.

Summary Introduction

To determine: The intracellular and interstitial fluid volume of a patient if the total body water volume is 42 L, ECF volume is found to be 12.5 L, and the plasma volume of the patient is 2.7 L.

Introduction: In humans, body fluid is present in different compartments forms. Body fluid in each compartment has its characteristics and functions to perform. These compartments in the body are separated by some form of physical barriers. Fluid in each of these compartments increases or decreases according to the physiological conditions of the body. Two of the main fluid compartments in the body are: Intracellular fluid (ICF) compartment; and Extracellular fluid (ECF) compartment.

Answer 8

b.

Summary Introduction

To determine: The amount of solute present in the whole body, ECF, ICF, and plasma of the patient.

Introduction: Different body fluids contain different amount of solute particles. Based on the concentration of solute present in the fluid, a concentration gradient is set up between the fluids. This concentration gradient is responsible for the movement of water across the boundaries. The concentration of these solutes is measured in terms of the osmolarity of the fluid.

Answer 9

b.

Summary Introduction

To determine: The amount of solute present in the whole body, ECF, ICF, and plasma of the patient.

Introduction: Different body fluids contain different amount of solute particles. Based on the concentration of solute present in the fluid, a concentration gradient is set up between the fluids. This concentration gradient is responsible for the movement of water across the boundaries. The concentration of these solutes is measured in terms of the osmolarity of the fluid.

Answer 10

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Answer 12

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Answer 13

Ch. 5.1 - If the 58-kg Reference Woman has total body water...Ch. 5.1 - A mother brings her baby to the emergency room...Ch. 5.1 - Prob. 6CC Ch. 5.1 - Two compartments are separated by a membrane that...Ch. 5.1 - Prob. 8CC Ch. 5.1 - Prob. 9CC Ch. 5.1 - Prob. 10CC Ch. 5.3 - If the distance over which a molecule must diffuse...Ch. 5.3 - Prob. 12CC Ch. 5.3 - Which is more likely to cross a cell membrane by...

Solution Summary: The author explains how to determine the intracellular and interstitial fluid volume of a patient.

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