Essential Cell Biology 5e
Essential Cell Biology 5e
5th Edition
ISBN: 9780393691108
Author: Bruce Alberts, Karen Hopkin, Alexander D Johnson, David Morgan, Martin Raff, Keith Roberts, Peter Wa
Publisher: W. W. Norton
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Chapter 5, Problem 2Q
Summary Introduction

To calculate: The volume of the nucleus occupied by histone octamers.

Introduction: Cell is the basic unit of life. It contains a nucleus that has the genetic material as DNA. The monomers that make up the DNA are nucleotides. There are four different nucleotides. These are adenine (A), thymine (T), cytosine (C), and guanine (G). The nucleotides are covalently joined together in a sequence through the sugars and phosphates. This forms a backbone of alternating sugar-phosphate–sugar-phosphate. The histone protein helps in chromosome packing into the nucleosome. An individual nucleosome core particle consists of a complex of eight histone proteins called histone octamers in which DNA is wrapped.

Summary Introduction

To calculate: The fraction of the total volume of the nucleus occupied by histone octamers.

Summary Introduction

To explain: How this can be compared with the volume of the nucleus occupied by human DNA.

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*Example 2: Tracing the path of an autosomal dominant trait Trait: Neurofibromatosis Forms of the trait: The dominant form is neurofibromatosis, caused by the production of an abnormal form of the protein neurofibromin. Affected individuals show spots of abnormal skin pigmentation and non-cancerous tumors that can interfere with the nervous system and cause blindness. Some tumors can convert to a cancerous form. i The recessive form is a normal protein - in other words, no neurofibromatosis.moovi A typical pedigree for a family that carries neurofibromatosis is shown below. Note that carriers are not indicated with half-colored shapes in this chart. Use the letter "N" to indicate the dominant neurofibromatosis allele, and the letter "n" for the normal allele. Nn nn nn 2 nn Nn A 3 N-
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