
Concept explainers
To explain: Whether the viral DNA has single unique origin of replication or several origins.
Introduction:
During
To explain: Whether the replication is unidirectional or bidirectional.
Introduction:
During DNA replication, each of the original DNA strands serves as a template for the formation of entire new strand. DNA polymerase synthesize DNA strand by adding deoxyribonucleoside triphosphates on single strand DNA template. The localized region of the DNA called origin of replication where DNA replication begins forms replication fork. The replication fork is a Y-shaped structure which moves progressively along the parental DNA double helix. At the replication fork, the DNA polymerase synthesizes the DNA of both daughter strands. As the DNA synthesis continues the tension in double strand DNA increases which is relieved by topoisomerase. The direction of DNA synthesis is 5’ to 3’. The leading strand of the DNA synthesizes continuously on one template strand, and the lagging strand synthesizes discontinusly on another DNA strand. The small fragment of DNA on lagging strand is called Okazaki fragment. For the lagging strand the direction of nucleotide polymerization is opposite to the overall direction of DNA chain growth.

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Chapter 5 Solutions
Molecular Biology of the Cell (Sixth Edition)
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