Campbell Biology: Custom Edition
18th Edition
ISBN: 9781323717271
Author: Urry, Cain, Wasserman, Minorsky, Reece
Publisher: PEARSON C
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Textbook Question
Chapter 49, Problem 1TYU
Activation of the parasympathetic branch of the autonomic nervous system
- (A) increases heart rate.
- (B) enhances digestion.
- (C) triggers release of epinephrine.
(D) causes conversion of glycogen to glucose.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
Chapter 49 Solutions
Campbell Biology: Custom Edition
Ch. 49.1 - Which division of the autonomic nervous system...Ch. 49.1 - Prob. 2CCCh. 49.1 - Prob. 3CCCh. 49.2 - When you wave your right hand, what part of your...Ch. 49.2 - People who are inebriated have difficulty touching...Ch. 49.2 - Prob. 3CCCh. 49.3 - How can studying individuals with damage to a...Ch. 49.3 - Prob. 2CCCh. 49.3 - Prob. 3CCCh. 49.4 - How can studying individuals with damage to a...
Ch. 49.4 - Individuals with localized brain damage have been...Ch. 49.4 - WHAT IF? Suppose that a person with damage to the...Ch. 49.5 - Prob. 1CCCh. 49.5 - Prob. 2CCCh. 49.5 - WHAT IF? If you could detect early-stage...Ch. 49 - How does the circuitry of a reflex facilitate a...Ch. 49 - What roles do the midbrain, cerebellum, thalamus,...Ch. 49 - A patient has trouble with language and has...Ch. 49 - Prob. 49.4CRCh. 49 - Prob. 49.5CRCh. 49 - Activation of the parasympathetic branch of the...Ch. 49 - Prob. 2TYUCh. 49 - Patients with damage to Wernickes area have...Ch. 49 - The cerebral cortex does not play a major role in...Ch. 49 - After suffering a stroke, a patient can see...Ch. 49 - Injury localized to the hypothalamus would most...Ch. 49 - Prob. 7TYUCh. 49 - Prob. 8TYUCh. 49 - SCIENTIFIC INQUIRY Consider an individual who had...Ch. 49 - Prob. 10TYUCh. 49 - WRITE ABOUT A THEME: INFORMATION In a short essay...Ch. 49 - SYNTHESIZE YOUR KNOWLEDGE Imagine you are standing...
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