BIO 1406/07 BK/LAB/CODE PREPACK
BIO 1406/07 BK/LAB/CODE PREPACK
12th Edition
ISBN: 9781265538590
Author: Raven
Publisher: MCG
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Chapter 49, Problem 1DA
Summary Introduction

To determine: Whether the higher glucose concentration in blood than it can be reabsorbed in the kidney would result in loss or gain of water.

Introduction: Maintenance of osmotic balance in tissues is essential to perform different metabolic functions. Osmoregulation and maintenance of body fluid levels ensure proper thermoregulation, sufficient organ perfusion, electrolyte balance, and excretion of wastes. The loop of Henle is present with nephrons in birds and mammals. Hypertonic urine production is achieved by the loop of Henle part of the nephron. In the loop of Henle, water and monovalent ions like Cl- and Na+ are reabsorbed.

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Reabsorption refers to the selective movement of solutes, like amino acids, glucose, and several other inorganic ions, from the filtrate present in the tubules system to the body fluids. Further, they move back into the blood stream through surrounding peritubular capillaries. Reabsorption of water also occurs and this process can be controlled for regulating the extent of water loss. When the glucose concentration is about 180 mg/100 mL in blood, saturation occurs. In untreated diabetes mellitus, the glucose concentration in blood exceeds this quantity. The glucose molecules that remain in the glomerular filtrate are then eliminated in the urine. An increase in the quantity of glucose in the blood would decrease the quantity of water that is reabsorbed, thus ultimately resulting in the loss of water.

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a. What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent.  b. What will happen to elimination of the drug in the previous question if the system is saturated? explain and show any math involved
If you wanted to reduce the difference between peak and trough levels that occur with repeated administration of a drug, how would you adjust the dose and dose interval without changing the plateau concentration (plateau is the average of peak and trough levels)? Select your answers for both dose and interval. Hint: It may be helpful to think about this problem using an example such as food. How would you eat if you wanted to maintain very steady hunger/satiety levels without changing your total caloric intake? Options: A. Dose; Increase dose     B. Dose; Decrease dose     C. Dose; Do not change dose     D. Interval; Increase the interval between doses (give the drug less frequently)    E. Interval; Decrease the interval between doses (give the drug more frequently)     F. Interval; Do not change the interval
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