Foundations in Microbiology
9th Edition
ISBN: 9780073522609
Author: Kathleen Park Talaro, Barry Chess Instructor
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 4.7, Problem 37CYP
Name two main groups of obligate intracellular
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 4 Solutions
Foundations in Microbiology
Ch. 4.1 - Describe the fundamental characteristics of cells.Ch. 4.1 - Identify the primary properties that define life...Ch. 4.1 - Prob. 1CYPCh. 4.1 - Name several general characteristics that could be...Ch. 4.2 - Describe the generalized anatomy of bacterial...Ch. 4.2 - Prob. 4ELOCh. 4.2 - Describe the structure and position of bacterial...Ch. 4.2 - Explain how flagella influence motility and motile...Ch. 4.2 - Prob. 7ELOCh. 4.2 - Define glycocalyx, and describe its different...
Ch. 4.2 - What other microbial groups besides bacteria have...Ch. 4.2 - Prob. 4CYPCh. 4.2 - How does the flagellum dictate the behavior of a...Ch. 4.2 - Differentiate between the structure and functions...Ch. 4.2 - Prob. 7CYPCh. 4.2 - Prob. 8CYPCh. 4.2 - Prob. 9CYPCh. 4.2 - Explain how the bacterial glycocalyx and certain...Ch. 4.3 - Prob. 9ELOCh. 4.3 - Outline the structure and functions of cell walls,...Ch. 4.3 - Contrast the major structure of gram-positive and...Ch. 4.3 - Prob. 12ELOCh. 4.3 - Relate the characteristics of other types of cell...Ch. 4.3 - Prob. 14ELOCh. 4.3 - Prob. 11CYPCh. 4.3 - Prob. 12CYPCh. 4.3 - Prob. 13CYPCh. 4.3 - How does the precise structure of the cell walls...Ch. 4.3 - Prob. 15CYPCh. 4.3 - Prob. 16CYPCh. 4.3 - Describe the medical impact of the cell walls of...Ch. 4.3 - Prob. 18CYPCh. 4.3 - Prob. 19CYPCh. 4.4 - Prob. 15ELOCh. 4.4 - Prob. 16ELOCh. 4.4 - Characterize the bacterial ribosomes and...Ch. 4.4 - Prob. 18ELOCh. 4.4 - Prob. 19ELOCh. 4.4 - Discuss the resistance and significance of...Ch. 4.4 - Prob. 20CYPCh. 4.4 - What is unique about the structure of bacterial...Ch. 4.4 - Prob. 22CYPCh. 4.4 - Prob. 23CYPCh. 4.4 - Describe the way endospores are formed, their...Ch. 4.4 - Prob. 25CYPCh. 4.4 - Why are spores so difficult to destroy?Ch. 4.5 - Describe the shapes of bacteria and their possible...Ch. 4.5 - Prob. 22ELOCh. 4.5 - Outline the size ranges among bacteria and in...Ch. 4.5 - Prob. 27CYPCh. 4.5 - Prob. 28CYPCh. 4.5 - What are vibrios and coccobacilli?Ch. 4.5 - Prob. 30CYPCh. 4.5 - Prob. 31CYPCh. 4.5 - Prob. 32CYPCh. 4.6 - Prob. 24ELOCh. 4.6 - Prob. 25ELOCh. 4.6 - Outline a basic system of bacterial taxonomy.Ch. 4.6 - Explain the species and subspecies levels for...Ch. 4.6 - Prob. 33CYPCh. 4.6 - Prob. 34CYPCh. 4.6 - Prob. 35CYPCh. 4.7 - Differentiate various groups of photosynthetic...Ch. 4.7 - Characterize the types of obligate intracellular...Ch. 4.7 - Prob. 30ELOCh. 4.7 - Prob. 31ELOCh. 4.7 - Prob. 32ELOCh. 4.7 - Prob. 36CYPCh. 4.7 - Name two main groups of obligate intracellular...Ch. 4.7 - Explain the characteristics of archaea that...Ch. 4.7 - Prob. 39CYPCh. 4.7 - Describe the three major archaeal lifestyles and...Ch. 4.L1 - Prob. 1MCQCh. 4.L1 - Viruses are not considered living things because...Ch. 4.L1 - Prob. 3MCQCh. 4.L1 - Prob. 4MCQCh. 4.L1 - Pili are appendages in _________ bacteria that...Ch. 4.L1 - Prob. 6MCQCh. 4.L1 - Which of the following is a primary bacterial cell...Ch. 4.L1 - Which of the following is present in both...Ch. 4.L1 - Metachromatic granules are concentrated ________...Ch. 4.L1 - Prob. 10MCQCh. 4.L1 - Prob. 11MCQCh. 4.L1 - Prob. 12MCQCh. 4.L1 - Prob. 13MCQCh. 4.L1 - Prob. 14MCQCh. 4.L1 - Prob. 15MCQCh. 4.L1 - To which taxonomic group do cyanobacteria belong?...Ch. 4.L1 - Prob. 17MCQCh. 4.L1 - The first living cells on earth would most likely...Ch. 4.L1 - Prob. 1CSRCh. 4.L1 - Prob. 2CSRCh. 4.L1 - What is a biofilm, and how did it form on the...Ch. 4.L1 - Label the parts on the bacterial cell featured...Ch. 4.L1 - Discuss the collection of properties that are used...Ch. 4.L1 - Describe the basic process of biofilm formation.Ch. 4.L1 - Prob. 4WCCh. 4.L1 - Prob. 5WCCh. 4.L2 - Using clay, demonstrate how cocci can divide in...Ch. 4.L2 - Prob. 2CTCh. 4.L2 - Prob. 3CTCh. 4.L2 - Prob. 4CTCh. 4.L2 - a. Name a bacterial group that uses chlorophyll to...Ch. 4.L2 - Propose a hypothesis to explain how bacteria and...Ch. 4.L2 - Prob. 7CTCh. 4.L2 - Prob. 8CTCh. 4.L2 - Describe the shapes and arrangements of bacteria...Ch. 4.L2 - Prob. 1VCCh. 4.L2 - What kinds of cells are shown here? Explain what...
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