CONNECT FOR SEELEY'S ANAT & PHYS
12th Edition
ISBN: 9781264052325
Author: VanPutte
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 4.6, Problem 49AYP
Differentiate among multipolar, bipolar, and pseudounipolar neurons.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 4 Solutions
CONNECT FOR SEELEY'S ANAT & PHYS
Ch. 4.1 - What components make up a tissue?Ch. 4.1 - Name the four primary tissue types and the...Ch. 4.1 - Define histology. Explain how the histology of...Ch. 4.2 - Name the three embryonic germ layers.Ch. 4.2 - Prob. 5AYPCh. 4.2 - List six characteristics common to most types of...Ch. 4.3 - List six characteristics common to most types of...Ch. 4.3 - What are the distinct cell surfaces found in...Ch. 4.3 - List and describe the major functions of...Ch. 4.3 - Describe simple, stratified, and pseudo stratified...
Ch. 4.3 - How do nonkeratinized stratified squarmous...Ch. 4.3 - Prob. 12AYPCh. 4.3 - List the types of epithelial tissue, giving the...Ch. 4.3 - Prob. 14AYPCh. 4.3 - Prob. 15AYPCh. 4.3 - What is the function of each of the following...Ch. 4.3 - Prob. 17AYPCh. 4.3 - Prob. 18AYPCh. 4.3 - What is the general function of gap junctions?Ch. 4.3 - Prob. 20AYPCh. 4.3 - Prob. 21AYPCh. 4.3 - Prob. 22AYPCh. 4.4 - What is the main characteristic that distinguishes...Ch. 4.4 - List the major functions of connective tissue, and...Ch. 4.4 - Explain th differences among blast. cyte, and...Ch. 4.4 - Prob. 26AYPCh. 4.4 - Contrast the structure and characteristics of...Ch. 4.4 - Describe the structure and functions of hyaluronic...Ch. 4.4 - Prob. 29AYPCh. 4.4 - List the two types of embryonic tissue. What does...Ch. 4.4 - What are the three classification of adult...Ch. 4.4 - Prob. 32AYPCh. 4.4 - Prob. 33AYPCh. 4.4 - Name the two types of adipose tissue, and give the...Ch. 4.4 - Prob. 35AYPCh. 4.4 - Prob. 36AYPCh. 4.4 - Name the two kinds of dense regular connective...Ch. 4.4 - Prob. 38AYPCh. 4.4 - Prob. 39AYPCh. 4.4 - Prob. 40AYPCh. 4.4 - What characteristic separates blood from other...Ch. 4.4 - Describe the function of hemopoietic tissue....Ch. 4.5 - Functionally, what is unique about muscle tissue?Ch. 4.5 - Compare the structure of skeletal, cardiac, and...Ch. 4.5 - Prob. 45AYPCh. 4.5 - Prob. 46AYPCh. 4.6 - What is the characteristic function of nervous...Ch. 4.6 - Prob. 48AYPCh. 4.6 - Differentiate among multipolar, bipolar, and...Ch. 4.6 - Prob. 50AYPCh. 4.7 - Prob. 51AYPCh. 4.7 - What are the functions of mucous serous and...Ch. 4.8 - What is the function of the inflammatory response?Ch. 4.8 - Prob. 54AYPCh. 4.9 - Define tissue repair. Differentiate between repair...Ch. 4.9 - Prob. 56AYPCh. 4.9 - Prob. 57AYPCh. 4.9 - What is granulation tissue? How does granulation...Ch. 4.10 - Prob. 59AYPCh. 4.10 - Prob. 60AYPCh. 4.10 - Prob. 61AYPCh. 4 - Given these characteristics: (I) capable of...Ch. 4 - Which of these embryonic germ layers gives rise to...Ch. 4 - Prob. 3RACCh. 4 - Stratified epithelium is usually found in areas of...Ch. 4 - Which of these characteristics do not describe...Ch. 4 - Prob. 6RACCh. 4 - Prob. 7RACCh. 4 - Pseudo stratified ciliated columnar epithelium can...Ch. 4 - Prob. 9RACCh. 4 - Prob. 10RACCh. 4 - A ________ gland has a duct that branches...Ch. 4 - Prob. 12RACCh. 4 - Mesenchymal cells a. form embryonic connective...Ch. 4 - Prob. 14RACCh. 4 - Prob. 15RACCh. 4 - Prob. 16RACCh. 4 - Which of these is not true of adipose tissue? a....Ch. 4 - Which of these types of connective tissue has the...Ch. 4 - Prob. 19RACCh. 4 - Prob. 20RACCh. 4 - Prob. 21RACCh. 4 - Which of these statements about nervous tissue is...Ch. 4 - The linings of the digestive, respiratory,...Ch. 4 - Prob. 24RACCh. 4 - Which of these types of cells is labile? a. neuron...Ch. 4 - Prob. 26RACCh. 4 - Given the observation that a tissue has more than...Ch. 4 - Prob. 2CTCh. 4 - Prob. 3CTCh. 4 - Prob. 4CTCh. 4 - Prob. 5CTCh. 4 - Prob. 6CT
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