Phase I of a Clinical Trial A clinical test on humans of a new drug is normally done in three phases. Phase I is conducted with a relatively small number of healthy volunteers. For example, a phase I test of bexarotene involved only 14 subjects. Assume that we want to treat 14 healthy humans with this new drug and we have 16 suitable volunteers available.
a. If the subjects are selected and treated one at a time in sequence, how many different sequential arrangements are possible if 14 people are selected from the 16 that are available?
b. If 14 subjects are selected from the 16 that are available, and the 14 selected subjects are all treated at the same time, how many different treatment groups are possible?
c. If 14 subjects are randomly selected and treated at the same time, what is the
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Chapter 4 Solutions
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- Exercise 4.2 Prove that, if A and B are independent, then so are A and B, Ac and B, and A and B.arrow_forward8. Show that, if {Xn, n ≥ 1) are independent random variables, then sup X A) < ∞ for some A.arrow_forward8- 6. Show that, for any random variable, X, and a > 0, 8 心 P(xarrow_forward15. This problem extends Problem 20.6. Let X, Y be random variables with finite mean. Show that 00 (P(X ≤ x ≤ Y) - P(X ≤ x ≤ X))dx = E Y — E X.arrow_forward(b) Define a simple random variable. Provide an example.arrow_forward17. (a) Define the distribution of a random variable X. (b) Define the distribution function of a random variable X. (c) State the properties of a distribution function. (d) Explain the difference between the distribution and the distribution function of X.arrow_forward16. (a) Show that IA(w) is a random variable if and only if A E Farrow_forward15. Let 2 {1, 2,..., 6} and Fo({1, 2, 3, 4), (3, 4, 5, 6}). (a) Is the function X (w) = 21(3, 4) (w)+711.2,5,6) (w) a random variable? Explain. (b) Provide a function from 2 to R that is not a random variable with respect to (N, F). (c) Write the distribution of X. (d) Write and plot the distribution function of X.arrow_forward20. Define the o-field R2. Explain its relation to the o-field R.arrow_forward7. Show that An → A as n→∞ I{An} - → I{A} as n→ ∞.arrow_forward7. (a) Show that if A,, is an increasing sequence of measurable sets with limit A = Un An, then P(A) is an increasing sequence converging to P(A). (b) Repeat the same for a decreasing sequence. (c) Show that the following inequalities hold: P (lim inf An) lim inf P(A) ≤ lim sup P(A) ≤ P(lim sup A). (d) Using the above inequalities, show that if A, A, then P(A) + P(A).arrow_forward19. (a) Define the joint distribution and joint distribution function of a bivariate ran- dom variable. (b) Define its marginal distributions and marginal distribution functions. (c) Explain how to compute the marginal distribution functions from the joint distribution function.arrow_forwardarrow_back_iosSEE MORE QUESTIONSarrow_forward_ios
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