The term “MHC” denotes “Major Histocompatibility Complex” molecule. This molecule is the host protein that presents the “antigen fragment” on the surface of the cell. It is essential for “T cells” to make out the foreign antigen. In the same manner, the “MHC molecules” identify the cells from another person as foreign and attack them. This is called immune rejection. These MHC molecules are identical between identical twins, so there will not be immune rejection if an organ is transplanted between identical twins.

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Biopharmaceutics and Pharmacokinetics:Two-Compartment Model Instant Absorption Questions Calculate these : a) B1, b) B2, c) hybrid rate constant (1) d) hybrid rate constant (2) e) t1/2,dist f) t1/2,elim g) k10 h) k12 i) k21 j) initial concentration (C0) k) central compartment volume (V1) l) steady-state volume (Vss) m) clearance (CL) AUC (0→10 min) using trapezoidal rule n) AUC (20→30 min) using trapezoidal rule o) AUCtail (AUC360→∞) p) total AUC (using short cut method) q) volume from AUC (VAUC)

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Chapter 43, Problem 5TYU

Summary Introduction

Introduction: The term “MHC” denotes “Major Histocompatibility Complex” molecule. This molecule is the host protein that presents the “antigen fragment” on the surface of the cell. It is essential for “T cells” to make out the foreign antigen. In the same manner, the “MHC molecules” identify the cells from another person as foreign and attack them. This is called immune rejection. These MHC molecules are identical between identical twins, so there will not be immune rejection if an organ is transplanted between identical twins.

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