The term “MHC” denotes “Major Histocompatibility Complex” molecule. This molecule is the host protein that presents the “antigen fragment” on the surface of the cell. It is essential for “T cells” to make out the foreign antigen. In the same manner, the “MHC molecules” identify the cells from another person as foreign and attack them. This is called immune rejection. These MHC molecules are identical between identical twins, so there will not be immune rejection if an organ is transplanted between identical twins.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

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Chapter 43, Problem 5TYU

Summary Introduction

Introduction: The term “MHC” denotes “Major Histocompatibility Complex” molecule. This molecule is the host protein that presents the “antigen fragment” on the surface of the cell. It is essential for “T cells” to make out the foreign antigen. In the same manner, the “MHC molecules” identify the cells from another person as foreign and attack them. This is called immune rejection. These MHC molecules are identical between identical twins, so there will not be immune rejection if an organ is transplanted between identical twins.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

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