Anatomy & Physiology: An Integrative Approach
2nd Edition
ISBN: 9780078024283
Author: Michael McKinley Dr., Valerie O'Loughlin, Theresa Bidle
Publisher: McGraw-Hill Education
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Chapter 4.10, Problem 33WDYL
What are the specific changes that occur to DNA during apoptosis?
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. Consider a base substitution mutation that occurred in a DNA sequence that resulted in a change in the
encoded protein from the amino acid glutamic acid to aspartic acid. Normally the glutamic acid amino acid
is located on the outside of the soluble protein but not near an active site.
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A. What type of mutation occurred?
O-H
B. What 2 types of chemical bonds are found in the R-groups
of each amino acid? The R groups are shaded.
CH2
CH2
CH2
H2N-C-COOH
H2N-C-COOH
1
H
Glutamic acid
H
Aspartic acid
C. What 2 types of bonds could each R-group of each of these amino acids form with other molecules?
D. Consider the chemical properties of the two amino acids and the location of the amino acid in the
protein. Explain what effect this mutation will have on this protein's function and why.
engineered constructs that consist of hollow fibers are acting as synthetic capillaries, around which cells have been loaded. The cellular space around a single fiber can be modeled as if it were a Krogh tissue cylinder. Each fiber has an outside “capillary” radius of 100 µm and the “tissue” radius can be taken as 200 µm. The following values apply to the device:R0 = 20 µM/secaO2 = 1.35 µM/mmHgDO2,T = 1.67 x 10-5 cm2/secPO2,m = 4 x 10-3 cm/secInstead of blood inside the fibers, the oxygen transport and tissue consumption are being investigated by usingan aqueous solution saturated with pure oxygen. As a result, there is no mass transfer resistance in the synthetic“capillary”, only that due to the membrane itself. Rather than accounting for pO2 variations along the length ofthe fiber, use an average value in the “capillary” of 130 mmHg.Is the tissue fully oxygenated?
Molecular Biology
Please help with question. thank you
You are studying the expression of the lac operon. You have isolated mutants as described below. In the presence of glucose, explain/describe what would happen, for each mutant, to the expression of the lac operon when you add lactose AND what would happen when the bacteria has used up all of the lactose (if the mutant is able to use lactose).5. Mutations in the lac operator that strengthen the binding of the lac repressor 200 fold
6. Mutations in the promoter that prevent binding of RNA polymerase
7. Mutations in CRP/CAP protein that prevent binding of cAMP8. Mutations in sigma factor that prevent binding of sigma to core RNA polymerase
Chapter 4 Solutions
Anatomy & Physiology: An Integrative Approach
Ch. 4.1 - What is the advantage of using a TEM instead of an...Ch. 4.1 - Prob. 2WDYLCh. 4.1 - What are the three main structural features of a...Ch. 4.2 - What cellular structure is responsible for forming...Ch. 4.2 - How do lipids maintain the basic physical barrier...Ch. 4.2 - What type of plasma membrane protein provides the...Ch. 4.3 - How does O2 diffuse into a cell and CO2 diffuse...Ch. 4.3 - Compare and contrast how an ion is transported...Ch. 4.3 - Define osmosis.Ch. 4.3 - What occurs to the tonicity of a cell when it is...
Ch. 4.3 - What general conclusion can you make concerning...Ch. 4.3 - What transport process involved in the movement of...Ch. 4.3 - Engulfing of a bacterium by a white blood cell...Ch. 4.4 - Define a resting membrane potential.Ch. 4.4 - Explain how the resting membrane potential is...Ch. 4.5 - What are some examples of how cells communicate...Ch. 4.5 - How do action of enzymatic receptors and G...Ch. 4.6 - Describe the general structure of both the...Ch. 4.6 - Lysosomes and peroxisomes are both small...Ch. 4.6 - Which non-membrane-bound organelle functions (a)...Ch. 4.6 - Which cellular surface structure functions in (a)...Ch. 4.6 - Which cellular junction (a) provides resistance to...Ch. 4.7 - What is the function of nuclear pores within the...Ch. 4.7 - What is the function of the nucleolus?Ch. 4.7 - Describe the structural relationship of DNA and...Ch. 4.8 - What are the three major structures required for...Ch. 4.8 - What is a codon and an anticodon?Ch. 4.8 - How is mRNA attached to ribosomes and translated...Ch. 4.8 - The genetic code of DNA is the specific...Ch. 4.9 - How is chromatin distinguished from a chromosome?Ch. 4.9 - Describe the process of DNA replication that...Ch. 4.9 - What are the events that occur during the mitotic...Ch. 4.10 - What are the specific changes that occur to DNA...Ch. 4 - All of the following general functions are carried...Ch. 4 - _____ 2. The molecule that is responsible for most...Ch. 4 - Prob. 3DYKBCh. 4 - Prob. 4DYKBCh. 4 - Prob. 5DYKBCh. 4 - Prob. 6DYKBCh. 4 - Prob. 7DYKBCh. 4 - Prob. 8DYKBCh. 4 - _____ 9. During this stage of mitosis, the...Ch. 4 - _____ 10. Erythrocytes do not have a nucleus. In...Ch. 4 - Prob. 11DYKBCh. 4 - Prob. 12DYKBCh. 4 - Describe the passive processes of membrane...Ch. 4 - Describe the active processes of membrane...Ch. 4 - List the membrane-bound structures, and describe...Ch. 4 - Prob. 16DYKBCh. 4 - Prob. 17DYKBCh. 4 - Prob. 18DYKBCh. 4 - Prob. 19DYKBCh. 4 - Explain the processes that occur in the different...Ch. 4 - Michael was born with Tay-Sachs disease. Which of...Ch. 4 - Prob. 2CALCh. 4 - Prob. 3CALCh. 4 - Prob. 4CALCh. 4 - Prob. 5CALCh. 4 - Prob. 1CSLCh. 4 - Prob. 2CSLCh. 4 - Prob. 3CSL
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