EBK CAMPBELL BIOLOGY IN FOCUS
2nd Edition
ISBN: 8220101459299
Author: Reece
Publisher: PEARSON
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Chapter 40, Problem 9TYU
FOCUS ON INTERACTIONS In a short essay (100-150 words), identify the factor or factors in Figure 40.23 that you think may ultimately be most important for density-dependent population regulation in humans, and explain your reasoning.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 40 Solutions
EBK CAMPBELL BIOLOGY IN FOCUS
Ch. 40.1 - Explain how the suns unequal heating of Earths...Ch. 40.1 - WHAT IF? If global warming increases average...Ch. 40.2 - Why are phytoplankton and not benthic algae or...Ch. 40.2 - Prob. 2CCCh. 40.2 - WHAT IF? Water leaving a reservoir behind the dam...Ch. 40.3 - Give examples of human actions that could expand a...Ch. 40.3 - WHAT IF? You suspect that deer are restricting the...Ch. 40.4 - DRAW IT Each female of a particular fish species...Ch. 40.4 - Imagine that you are constructing a life table for...Ch. 40.4 - Prob. 3CC
Ch. 40.5 - Explain why a constant rate of increase (r) for a...Ch. 40.5 - Explain why a population that fits the logistic...Ch. 40.5 - Prob. 3CCCh. 40.6 - Prob. 1CCCh. 40.6 - WHAT IF? Mice that experience stress such as a...Ch. 40.6 - Prob. 3CCCh. 40 - Which of the following biomes is correctly paired...Ch. 40 - A populations carrying capacity A. may change as...Ch. 40 - When climbing a mountain, we can observe...Ch. 40 - According to the logistic growth equation...Ch. 40 - WHAT IF? If the direction of Earths rotation...Ch. 40 - INTERPRET THE DATA After examining Figure 40.13,...Ch. 40 - SCIENTIFIC INQUIRY Jens Clausen and colleagues, at...Ch. 40 - Prob. 8TYUCh. 40 - FOCUS ON INTERACTIONS In a short essay (100-150...Ch. 40 - SYNTHESIZE YOUR KNOWLEDGE Locusts (a type of...
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