Principles of Biology
Principles of Biology
2nd Edition
ISBN: 9781259875120
Author: Robert Brooker, Eric P. Widmaier Dr., Linda Graham Dr. Ph.D., Peter Stiling Dr. Ph.D.
Publisher: McGraw-Hill Education
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Chapter 4, Problem 7TY
Summary Introduction

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The proteins that are supposed to reach areas of the cell other than the endoplasmic reticulum or the Golgi apparatus are moved through the cisternae of the Golgi towards the trans-face, to a complex network of membranes and the associated vesicles that are referred to as trans-Golgi-network (TGN).

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22. Which of the following mutant proteins is expected to have a dominant negative effect when over-   expressed in normal cells?   a. mutant PI3-kinase that lacks the SH2 domain but retains the kinase function   b. mutant Grb2 protein that cannot bind to RTK   c. mutant RTK that lacks the extracellular domain   d. mutant PDK that has the PH domain but lost the kinase function   e. all of the above
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