Our Origins: Discovering Physical Anthropology (Fourth Edition)
Our Origins: Discovering Physical Anthropology (Fourth Edition)
4th Edition
ISBN: 9780393614008
Author: Clark Spencer Larsen
Publisher: W. W. Norton & Company
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Chapter 4, Problem 3ER
Summary Introduction

To define: The environmental agents that could increase the rates of genetic mutations among humans today.

Introduction: Mutation is the alteration that occurs in the DNA sequence. It occurs either due to the results of the environmental factors such as UV light or mistakes when the DNA is copied. Mutation plays a part in abnormal and normal biological processes including cancer, evolution, and development of the immune system.

Summary Introduction

To define: The types of the mutation have the potential to be most significant from an evolutionary perspective.

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22. Which of the following mutant proteins is expected to have a dominant negative effect when over-   expressed in normal cells?   a. mutant PI3-kinase that lacks the SH2 domain but retains the kinase function   b. mutant Grb2 protein that cannot bind to RTK   c. mutant RTK that lacks the extracellular domain   d. mutant PDK that has the PH domain but lost the kinase function   e. all of the above
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