EP PRINCIPLES OF HUM.PHYS.-MOD.MAST.A+P
EP PRINCIPLES OF HUM.PHYS.-MOD.MAST.A+P
6th Edition
ISBN: 9780134407166
Author: STANFIELD
Publisher: PEARSON CO
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Chapter 4, Problem 22E
Summary Introduction

To write:

In cholera disease, the bacterial toxins excite some epithelial cells of the small intestine to oversecrete solutes into the lumen. This results in the transport of water across the intestinal epithelium. There is a resulting clinical sign due to this altered transport.

Introduction:

Cholera is an infection in the small intestine by some strains of the Vibrio cholerae bacterium. Cholera toxin stimulates the adenylate cyclase enzyme in the intestinal mucosa cells. It leads to the increased intracellular cAMP levels and the secretion of H2O, Na+, K+, Cl-, and HCO3- into the small intestine lumen.

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