Campbell Essential Biology (7th Edition)
Campbell Essential Biology (7th Edition)
7th Edition
ISBN: 9780134765037
Author: Eric J. Simon, Jean L. Dickey, Jane B. Reece
Publisher: PEARSON
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Chapter 4, Problem 16BS

Doctors at a university medical center removed John Moore’s spleen, which is a standard treatment for his type of leukemia. The disease did not recur. Researchers kept the spleen cells alive in a nutrient medium. They found that some cells produced a blood protein that showed prom se as a treatment for cancer and AIDS. The researchers patentes the cells. Moore sued, claiming a share in profits from any products derived from his cells. The U.S. Supreme Court ruled against Moore, stating that his lawsuit "threatens to destroy the economic incentive to conduct important medical research.” Moore argued that the ruling left patients "vulnerable to exploitation at the hands of the state." Do you think Moore was treated fairly? What else would you like to know about this case that might help you decide?

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The metabolic pathway below is used for the production of the purine nucleotides adenosine monophosphate (AMP) and guanosine monophosphate (GMP) in eukaryotic cells. Assume each arrow represents a reaction catalyzed by a different enzyme. Using the principles of feedback inhibition, propose a regulatory scheme for this pathway that ensures an adequate supply of both AMP and GMP, and prevents the buildup of Intermediates A through G when supplies of both AMP and GMP are adequate.
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