In a living organism, there are different types of biochemical reactions going on simultaneously. Some of these reactions results in production of energy while others are energy consuming reactions. All these reactions are very important for carrying out the important biological processes in the body.

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Chapter 4, Problem 13RQ

Summary Introduction

Introduction: In a living organism, there are different types of biochemical reactions going on simultaneously. Some of these reactions results in production of energy while others are energy consuming reactions. All these reactions are very important for carrying out the important biological processes in the body.

Summary Introduction

To determine: The units in which energy of metabolism is measured.

Introduction: All the activities going on in a biological system requires energy in one form or another. During different biological processes, this energy is converted from one form into another. Each form of energy is measured in their respective SI Units.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…

The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?

Answer 2

Question

Chapter 4, Problem 13RQ

Summary Introduction

Introduction: In a living organism, there are different types of biochemical reactions going on simultaneously. Some of these reactions results in production of energy while others are energy consuming reactions. All these reactions are very important for carrying out the important biological processes in the body.

Summary Introduction

To determine: The units in which energy of metabolism is measured.

Introduction: All the activities going on in a biological system requires energy in one form or another. During different biological processes, this energy is converted from one form into another. Each form of energy is measured in their respective SI Units.

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Answer 3

Question

Chapter 4, Problem 13RQ

Summary Introduction

Introduction: In a living organism, there are different types of biochemical reactions going on simultaneously. Some of these reactions results in production of energy while others are energy consuming reactions. All these reactions are very important for carrying out the important biological processes in the body.

Summary Introduction

To determine: The units in which energy of metabolism is measured.

Introduction: All the activities going on in a biological system requires energy in one form or another. During different biological processes, this energy is converted from one form into another. Each form of energy is measured in their respective SI Units.

Expert Solution & Answer

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Answer 4

Question

Chapter 4, Problem 13RQ

Summary Introduction

Introduction: In a living organism, there are different types of biochemical reactions going on simultaneously. Some of these reactions results in production of energy while others are energy consuming reactions. All these reactions are very important for carrying out the important biological processes in the body.

Summary Introduction

To determine: The units in which energy of metabolism is measured.

Introduction: All the activities going on in a biological system requires energy in one form or another. During different biological processes, this energy is converted from one form into another. Each form of energy is measured in their respective SI Units.

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Answer 5

Chapter 4, Problem 13RQ

Summary Introduction

Introduction: In a living organism, there are different types of biochemical reactions going on simultaneously. Some of these reactions results in production of energy while others are energy consuming reactions. All these reactions are very important for carrying out the important biological processes in the body.

Summary Introduction

To determine: The units in which energy of metabolism is measured.

Introduction: All the activities going on in a biological system requires energy in one form or another. During different biological processes, this energy is converted from one form into another. Each form of energy is measured in their respective SI Units.

Answer 6

Chapter 4, Problem 13RQ

Summary Introduction

Introduction: In a living organism, there are different types of biochemical reactions going on simultaneously. Some of these reactions results in production of energy while others are energy consuming reactions. All these reactions are very important for carrying out the important biological processes in the body.

Answer 7

Chapter 4, Problem 13RQ

Summary Introduction

Introduction: In a living organism, there are different types of biochemical reactions going on simultaneously. Some of these reactions results in production of energy while others are energy consuming reactions. All these reactions are very important for carrying out the important biological processes in the body.

Answer 8

Summary Introduction

To determine: The units in which energy of metabolism is measured.

Introduction: All the activities going on in a biological system requires energy in one form or another. During different biological processes, this energy is converted from one form into another. Each form of energy is measured in their respective SI Units.

Answer 9

Summary Introduction

To determine: The units in which energy of metabolism is measured.

Introduction: All the activities going on in a biological system requires energy in one form or another. During different biological processes, this energy is converted from one form into another. Each form of energy is measured in their respective SI Units.

Answer 10

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Answer 12

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Answer 13

Ch. 4.1 - Which biomolecules always include nitrogen in...Ch. 4.1 - Prob. 2CC Ch. 4.1 - What is the difference between potential energy...Ch. 4.1 - Prob. 4CC Ch. 4.2 - Prob. 5CC Ch. 4.2 - Prob. 6CC Ch. 4.2 - Prob. 7CC Ch. 4.3 - Prob. 8CC Ch. 4.3 - Prob. 9CC Ch. 4.3 - Prob. 10CC

Solution Summary: The author explains how different types of biochemical reactions are important for carrying out the important biological processes in the body.

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