PRESCOTT'S MICROBILOGY
11th Edition
ISBN: 9781264075515
Author: WILLEY
Publisher: MCG
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Textbook Question
Chapter 39.4, Problem 1MI
How do the neurological effects of botulinum toxin differ from those of tetanus toxin?
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 39 Solutions
PRESCOTT'S MICROBILOGY
Ch. 39.1 - What organisms serve as the environmental...Ch. 39.1 - How is the M protein also thought to be involved...Ch. 39.1 - Prob. 3MICh. 39.1 - Why do you think chlamydiae differentiate into...Ch. 39.1 - Compare and contrast the means by which people...Ch. 39.1 - Prob. 3CCCh. 39.1 - What are the three major causes of meningitis? Why...Ch. 39.1 - Prob. 5CCCh. 39.1 - How do multidrug-resistant strains of tuberculosis...Ch. 39.1 - Prob. 7CC
Ch. 39.1 - What is the mechanism by which PTx kills host...Ch. 39.1 - Prob. 9CCCh. 39.1 - Prob. 10CCCh. 39.2 - What are the three stages of Lyme disease? What...Ch. 39.2 - Prob. 1CCCh. 39.2 - Prob. 2CCCh. 39.2 - Prob. 3CCCh. 39.2 - Prob. 4CCCh. 39.3 - What are the chief differences between tuberculoid...Ch. 39.3 - How does H. pylori increase the local pH in its...Ch. 39.3 - Prob. 3MICh. 39.3 - Prob. 4MICh. 39.3 - Prob. 5MICh. 39.3 - Prob. 1CCCh. 39.3 - Why do you think the slow growth rate of M. leprae...Ch. 39.3 - Prob. 3CCCh. 39.3 - Prob. 4CCCh. 39.3 - Prob. 5CCCh. 39.3 - Prob. 6CCCh. 39.3 - Prob. 7CCCh. 39.3 - What is the difference between S. aureus and MRSA?Ch. 39.3 - Prob. 9CCCh. 39.3 - Prob. 10CCCh. 39.3 - Prob. 11CCCh. 39.4 - How do the neurological effects of botulinum toxin...Ch. 39.4 - To which E. coli class does the strain 0157:H7...Ch. 39.4 - Prob. 1CCCh. 39.4 - Compare the gastroenteritis caused by Vibrio...Ch. 39.4 - Prob. 3CCCh. 39.4 - Prob. 4CCCh. 39.4 - Prob. 5CCCh. 39.4 - Prob. 6CCCh. 39.4 - Prob. 7CCCh. 39.5 - Prob. 1MICh. 39.5 - Prob. 1CCCh. 39.5 - Prob. 2CCCh. 39.5 - How is ornithosis transmitted?Ch. 39.5 - Prob. 4CCCh. 39.6 - What cells and tissues make up the pseudomembrane?Ch. 39.6 - Prob. 2MICh. 39.6 - In both C. difficileassociated disease and...Ch. 39.6 - Prob. 2CCCh. 39.6 - Prob. 3CCCh. 39.6 - Prob. 4CCCh. 39 - Prob. 1RCCh. 39 - Prob. 2RCCh. 39 - Prob. 3RCCh. 39 - Prob. 4RCCh. 39 - Prob. 5RCCh. 39 - Prob. 1ALCh. 39 - Prob. 2ALCh. 39 - Prob. 3ALCh. 39 - Prob. 4ALCh. 39 - Prob. 5ALCh. 39 - Prob. 6AL
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