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Investigating Biology Laboratory Manual (9th Edition)
9th Edition
ISBN: 9780134473468
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Jane B. Reece, Judith Giles Morgan, M. Eloise Brown Carter
Publisher: PEARSON
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Textbook Question
Chapter 39.1, Problem 1CC
What are the morphological differences between dark-and light-grown plants? Explain how etiolation helps a seedling compete successfully.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 39 Solutions
Investigating Biology Laboratory Manual (9th Edition)
Ch. 39.1 - What are the morphological differences between...Ch. 39.1 - Cycloheximide is a drug that inhibits protein...Ch. 39.1 - Prob. 3CCCh. 39.2 - Prob. 1CCCh. 39.2 - WHAT IF? If a plant has the double mutation err...Ch. 39.2 - MAKE CONNECTIONS What type of feedback process is...Ch. 39.3 - If an enzyme in field-grown soybean leaves is most...Ch. 39.3 - WHAT IF? If a plant flowers in a controlled...Ch. 39.3 - MAKE CONNECTIONS Plants detect the quality of...Ch. 39.4 - Prob. 1CC
Ch. 39.4 - Prob. 2CCCh. 39.4 - Prob. 3CCCh. 39.5 - What are some drawbacks of spraying fields with...Ch. 39.5 - Chewing insects mechanically damage plants and...Ch. 39.5 - Many fungal pathogens get food by causing plant...Ch. 39.5 - WHAT IF? Suppose a scientist finds that a...Ch. 39 - What are two common ways by which signal...Ch. 39 - Is there any truth to the old adage, "One bad...Ch. 39 - Why did plant physiologists propose the existence...Ch. 39 - Plants that have acclimated to drought stress are...Ch. 39 - Prob. 39.5CRCh. 39 - Prob. 1TYUCh. 39 - Prob. 2TYUCh. 39 - Prob. 3TYUCh. 39 - How may a plant respond to severe heat stress? (A)...Ch. 39 - Level 2: Application/Analysis 5. The signaling...Ch. 39 - If a long-day plant has a critical night length of...Ch. 39 - Prob. 7TYUCh. 39 - DRAW IT Indicate the response to each condition by...Ch. 39 - Level 3: Synthesis/Evaluation 9. EVOLUTION...Ch. 39 - SCIENTIFIC INQUIRY A plant biologist observed a...Ch. 39 - SCIENCE. TECHNOLOGY, AND SOCIETY Describe how our...Ch. 39 - Prob. 12TYUCh. 39 - Prob. 13TYU
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