CAMPBELL BIOLOGY MOD MASTERING (18 WEEK)
12th Edition
ISBN: 9780136920335
Author: Urry
Publisher: PEARSON
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Chapter 39, Problem 39.5CR
Summary Introduction
To determine: The way in which the insects can make plants more susceptible to pathogens.
Introduction: Epidermis is the outermost layer of the stem that acts as a protection to the plant. Beneath the epidermis, there is another protective layer called periderm. The epidermis and periderm act as physical barriers in order to prevent the plant from infections.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 39 Solutions
CAMPBELL BIOLOGY MOD MASTERING (18 WEEK)
Ch. 39.1 - Prob. 1CCCh. 39.1 - Cycloheximide is a drug that inhibits protein...Ch. 39.1 - Prob. 3CCCh. 39.2 - Prob. 1CCCh. 39.2 - WHAT IF? If a plant has the double mutation err...Ch. 39.2 - MAKE CONNECTIONS What type of feedback process is...Ch. 39.3 - If an enzyme in field-grown soybean leaves is most...Ch. 39.3 - WHAT IF? If a plant flowers in a controlled...Ch. 39.3 - Prob. 3CCCh. 39.4 - Prob. 1CC
Ch. 39.4 - Prob. 2CCCh. 39.4 - Prob. 3CCCh. 39.5 - Prob. 1CCCh. 39.5 - Chewing insects mechanically damage plants and...Ch. 39.5 - Many fungal pathogens get food by causing plant...Ch. 39.5 - Prob. 4CCCh. 39 - What are two common ways by which signal...Ch. 39 - Is there any truth to the old adage, "One bad...Ch. 39 - Why did plant physiologists propose the existence...Ch. 39 - Plants that have acclimated to drought stress are...Ch. 39 - Prob. 39.5CRCh. 39 - Prob. 1TYUCh. 39 - Prob. 2TYUCh. 39 - Prob. 3TYUCh. 39 - How may a plant respond to severe heat stress? (A)...Ch. 39 - Level 2: Application/Analysis 5. The signaling...Ch. 39 - If a long-day plant has a critical night length of...Ch. 39 - Prob. 7TYUCh. 39 - DRAW IT Indicate the response to each condition by...Ch. 39 - Level 3: Synthesis/Evaluation 9. EVOLUTION...Ch. 39 - SCIENTIFIC INQUIRY A plant biologist observed a...Ch. 39 - SCIENCE. TECHNOLOGY, AND SOCIETY Describe how our...Ch. 39 - Prob. 12TYUCh. 39 - Prob. 13TYU
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