EP CONNECT ONLINE ACCESS FOR BIOLOGY
20th Edition
ISBN: 9781260494655
Author: Raven
Publisher: MCG COURSE
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Chapter 39, Problem 2U
Summary Introduction
Introduction:
The plants are divided into two regional parts based upon the appearance of the eyes of the humans. The upper part of the plant is called shoot and the lower part of the plant is called root.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 39 Solutions
EP CONNECT ONLINE ACCESS FOR BIOLOGY
Ch. 39.1 - Compare the pigments phytochrome and chlorophyll.Ch. 39.1 - List growth responses influenced by phytochrome.Ch. 39.1 - Prob. 3LOCh. 39.2 - Prob. 1LOCh. 39.2 - Prob. 2LOCh. 39.3 - Prob. 1LOCh. 39.3 - Prob. 2LOCh. 39.3 - Prob. 3LOCh. 39.4 - Prob. 1LOCh. 39.4 - Prob. 2LO
Ch. 39.4 - Identify the types of biological molecules that...Ch. 39.5 - Discuss properties of hormones.Ch. 39.5 - Prob. 2LOCh. 39.5 - Prob. 3LOCh. 39 - Prob. 1DACh. 39 - Prob. 1IQCh. 39 - Prob. 2IQCh. 39 - Propose a mechanism to explain how seedlings could...Ch. 39 - Which of the following is stimulated by blue...Ch. 39 - Prob. 2UCh. 39 - Prob. 3UCh. 39 - Prob. 4UCh. 39 - Which of the following does NOT happen as a seed...Ch. 39 - Dwarf mutants can sometimes be induced to grow...Ch. 39 - Prob. 1ACh. 39 - If you were to plant a de-etiolated (det2) mutant...Ch. 39 - Prob. 3ACh. 39 - Which of the following defects would prevent...Ch. 39 - You have come up with a brilliant idea to stretch...Ch. 39 - You have identified a mutant Arabtdopsis plant...Ch. 39 - Which of the following might not be observed in a...Ch. 39 - Prob. 1SCh. 39 - Prob. 2SCh. 39 - The current model for gravitropism suggests that...Ch. 39 - Prob. 4S
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