Principles of Biology
2nd Edition
ISBN: 9781259875120
Author: Robert Brooker, Eric P. Widmaier Dr., Linda Graham Dr. Ph.D., Peter Stiling Dr. Ph.D.
Publisher: McGraw-Hill Education
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Chapter 38.2, Problem 1TYK
Summary Introduction
Introduction:
The blood vessels are the important constituent of the circulatory system. The main function of the blood vessels is to transport the blood throughout the body. The main components of the blood vessels are veins, arteries, and capillaries. Veins carry blood towards the heart and arteries carry the blood away from the heart.
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Outline a method for using apomixis to maintain feminized CannabisAssume apomixis is controlled by a single dominant gene. You can choose the type of apomixis: obligate or facultative, gametophytic or sporophytic. Discuss advantages and disadvantages of your proposed method.
Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 38 Solutions
Principles of Biology
Ch. 38.1 - Prob. 1TYKCh. 38.1 - The synthesis of which class of hormone requires...Ch. 38.2 - Prob. 1BCCh. 38.2 - Prob. 1TYKCh. 38.2 - Prob. 2TYKCh. 38.3 - Prob. 1BCCh. 38.3 - Prob. 1TYKCh. 38.3 - Prob. 2TYKCh. 38.4 - Prob. 1CCCh. 38.4 - Prob. 1TYK
Ch. 38.5 - Some children with short stature can be...Ch. 38.5 - Prob. 2TYKCh. 38.5 - Prob. 1CCCh. 38.6 - Prob. 1TYKCh. 38.7 - Prob. 1TYKCh. 38 - Prob. 1TYCh. 38 - Prob. 2TYCh. 38 - Which is false about polypeptide hormones? They...Ch. 38 - Which is false about the control of hormones? Many...Ch. 38 - Prob. 5TYCh. 38 - Prob. 6TYCh. 38 - Prob. 7TYCh. 38 - Prob. 8TYCh. 38 - Prob. 9TYCh. 38 - Prob. 10TYCh. 38 - What is the function of leptin, and what is the...Ch. 38 - Prob. 2CCQCh. 38 - A principle of biology is that living organisms...Ch. 38 - Prob. 1CBQCh. 38 - Discuss the role of the different steroid hormones...
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