Prescott's Microbiology
Prescott's Microbiology
11th Edition
ISBN: 9781260211887
Author: WILLEY, Sandman, Wood
Publisher: McGraw Hill
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Chapter 36, Problem 7AL
Summary Introduction

Vaccines are biological preparations that confer active acquired immunity against various diseases. Effective vaccines used for humans are made up of whole microorganism called whole-cell vaccines: inactivated or attenuated vaccines. Likewise, DNA vaccines are also used widely for protection against disease. This can be achieved by injecting genetically engineered DNA.

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22. Which of the following mutant proteins is expected to have a dominant negative effect when over-   expressed in normal cells?   a. mutant PI3-kinase that lacks the SH2 domain but retains the kinase function   b. mutant Grb2 protein that cannot bind to RTK   c. mutant RTK that lacks the extracellular domain   d. mutant PDK that has the PH domain but lost the kinase function   e. all of the above
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