HUMAN BIOLOGY
16th Edition
ISBN: 9781260233032
Author: Mader
Publisher: RENT MCG
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 3.4, Problem 1CYP
Summary Introduction
To describe:
The functions of the endoplasmic reticulum, Golgi apparatus, and lysosome.
Introduction:
Endoplasmic reticulum has two portions: Rough ER is studded with ribosomes, while smooth ER doesn’t have any ribosomes. Camillo Golgi discovered the presence of the Golgi apparatus in the cell. Lysosomes are membranous sacs that contain hydrolytic enzymes.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Outline a method for using apomixis to maintain feminized CannabisAssume apomixis is controlled by a single dominant gene. You can choose the type of apomixis: obligate or facultative, gametophytic or sporophytic. Discuss advantages and disadvantages of your proposed method.
Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 3 Solutions
HUMAN BIOLOGY
Ch. 3.1 - State the basic principles of the cell theory.Ch. 3.1 - Prob. 2LOCh. 3.1 - Prob. 3LOCh. 3.1 - Discuss how a researcher might use a GFP-labeled...Ch. 3.1 - How might a meal of a cheeseburger and fries be...Ch. 3.1 - Summarize the cell theory and state its importance...Ch. 3.1 - Prob. 2CYPCh. 3.1 - Prob. 3CYPCh. 3.2 - Distinguish between the structure of a prokaryotic...Ch. 3.2 - Identify the role of the plasma membrane and...
Ch. 3.2 - Summarize how eukaryotic cells evolved from...Ch. 3.2 - Summarize the role of the plasma membrane in a...Ch. 3.2 - Describe the main differences between a eukaryotic...Ch. 3.2 - Describe the possible evolution of the nucleus,...Ch. 3.3 - Prob. 1LOCh. 3.3 - Prob. 2LOCh. 3.3 - Explain how tonicity relates to the direction of...Ch. 3.3 - Compare passive-transport and active-transport...Ch. 3.3 - Summarize how eukaryotic cells move large...Ch. 3.3 - Summarize how the fluid-mosaic model describes the...Ch. 3.3 - Prob. 2CYPCh. 3.3 - Prob. 3CYPCh. 3.4 - Describe the structure of the nucleus and explain...Ch. 3.4 - Summarize the function of the organelles of the...Ch. 3.4 - 3. Explain the role and location of the...Ch. 3.4 - Prob. 1CYPCh. 3.4 - Explain how the nucleus, ribosomes, and rough...Ch. 3.4 - Prob. 3CYPCh. 3.5 - Prob. 1LOCh. 3.5 - Summarize the major protein fibers In the...Ch. 3.5 - Prob. 3LOCh. 3.5 - Prob. 4LOCh. 3.5 - Prob. 1CYPCh. 3.5 - Prob. 2CYPCh. 3.5 - Prob. 3CYPCh. 3.6 - Prob. 1LOCh. 3.6 - Prob. 2LOCh. 3.6 - Summarize the roles of the anaerobic and aerobic...Ch. 3.6 - Prob. 4LOCh. 3.6 - How might a meal of a cheeseburger and fries be...Ch. 3.6 - Even though Figure 3B does not indicate the need...Ch. 3.6 - Summarize the roles of enzymes in chemical...Ch. 3.6 - Prob. 2CYPCh. 3.6 - Explain why the ATP cycle resembles that of a...Ch. 3.6 - Prob. 4CYPCh. 3 - Prob. 1ACh. 3 - The cell theory states that all life comes from...Ch. 3 - Prob. 3ACh. 3 - 4.The endosymbiotic theory explains which of the...Ch. 3 - Which of the following is not part of the...Ch. 3 - Prob. 6ACh. 3 - Prob. 7ACh. 3 - Prob. 8ACh. 3 - Prob. 9ACh. 3 - Prob. 10ACh. 3 - Prob. 11ACh. 3 - Prob. 12ACh. 3 - The cytoskeleton of a cell consists of all of the...Ch. 3 - Prob. 14ACh. 3 - Prob. 15ACh. 3 - Prob. 16ACh. 3 - Prob. 17ACh. 3 - Prob. 18ACh. 3 - Prob. 1TCCh. 3 - Prob. 2TCCh. 3 - Prob. 3TC
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- List substitutions in your diet you could make to improve it based on what you know now about a balanced diet. For instance, if you like to drink soda, you might substitute skim milk or water for some of the soft drinks you consumed. List the item you wish to replace with the new item and what you hope to accomplish with that substitution. Be sure to choose foods you know that you'd enjoy and you consider more "healthful." If you feel your diet is already balanced, describe how you accomplish your balanced intake and when you began eating this way.arrow_forwardWhich single food item contained you ate for the 3 days with the most sodium?arrow_forwardSelect a diet and choose one site that provides credible information. Explain why the source itself and/or the information on the site is credible. This should be a report. This site should be different from U.S News and World Report. For full credit, you must include the following information and elaborate in detail: The diet name The main components of the diet The credible website name and link What makes the credible website credible?arrow_forward
- Select a diet and give a summary of the main components. Do a web search of the diet and choose one link that provides misinformation. Explain why the site itself and/or the information on the site is not credible. This should be a report. This site should be different from U.S News and World Report. For full credit, you must include the following information and elaborate in detail: The diet name The main components of the diet The misinformation website and link What misinformation is being provided in the other website and how did you determine it was not credible?arrow_forward1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.arrow_forward2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…arrow_forward
- The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?arrow_forwardView History Bookmarks Window Help Quarter cements ents ons (17) YouTube Which amino acids would you expect to find marked on the alpha helix? canvas.ucsc.edu ucsc Complaint and Grievance Process - Academic Personnel pach orations | | | | | | | | | | | | | | | | 000000 000000000 | | | | | | | | | | | | | | | | | | | | | | 00000000 scope vious De 48 12.415 KATPM FEB 3 F1 F2 80 F3 a F4 F5 2 # 3 $ 85 % tv N A の Mon Feb 3 10:24 PM Lipid bilayer Submit Assignment Next > ZOOM < Å DII 8 བ བ F6 16 F7 F8 F9 F10 34 F11 F12 & * ( 6 7 8 9 0 + 11 WERTY U { 0 } P deletearrow_forwardDifferent species or organisms research for ecologyarrow_forward
- What is the result of the following gram stain: positive ○ capsulated ○ acid-fast ○ negativearrow_forwardWhat type of stain is the image below: capsule stain endospore stain gram stain negative stain ASM MicrobeLibrary.org Keplingerarrow_forwardWhat is the result of the acid-fast stain below: Stock Images by Getty Images by Getty Images by Getty Images by Getty Image Getty Images St Soy Getty Images by Getty Images by Getty Images Joy Getty encapsulated O endosporulating negative ○ positivearrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Human Biology (MindTap Course List)BiologyISBN:9781305112100Author:Cecie Starr, Beverly McMillanPublisher:Cengage Learning
Concepts of BiologyBiologyISBN:9781938168116Author:Samantha Fowler, Rebecca Roush, James WisePublisher:OpenStax College
Biology (MindTap Course List)BiologyISBN:9781337392938Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. BergPublisher:Cengage Learning
Biology Today and Tomorrow without Physiology (Mi...BiologyISBN:9781305117396Author:Cecie Starr, Christine Evers, Lisa StarrPublisher:Cengage Learning
Human Physiology: From Cells to Systems (MindTap ...
Biology
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Human Biology (MindTap Course List)
Biology
ISBN:9781305112100
Author:Cecie Starr, Beverly McMillan
Publisher:Cengage Learning
Concepts of Biology
Biology
ISBN:9781938168116
Author:Samantha Fowler, Rebecca Roush, James Wise
Publisher:OpenStax College
Biology (MindTap Course List)
Biology
ISBN:9781337392938
Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Publisher:Cengage Learning
Biology Today and Tomorrow without Physiology (Mi...
Biology
ISBN:9781305117396
Author:Cecie Starr, Christine Evers, Lisa Starr
Publisher:Cengage Learning