Biological Science (6th Edition)
6th Edition
ISBN: 9780321976499
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Emily Taylor, Greg Podgorski, Jeff Carmichael
Publisher: PEARSON
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Question
Chapter 33, Problem 13PIAT
Summary Introduction
To review:
The differences in the uncoating step of the HIV (human immunodeficiency virus) and influenza virus.
Introduction:
HIV is the lentivirus that leads to infection and may lead to AIDS (acquired immunodeficiency syndrome). Influenza is a respiratory infection commonly known as flu caused by the influenza virus. The three types of flu viruses are influenza A, influenza B, and influenza C.
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Researchers studying the SARS-CoV-2 virus, also known as COVID-19, have found that the
virus is able to circumvent its host cell's normal defenses by leaving the cell via its lyso-
somes rather than its normal secretory vesicles, as illustrated in the figure below.
endoplasmic
reticulum
nucleus
disrupted
lysosomal functions
Entry and egress of the SARS-CoV-2 virus
A
Golgi complex
Which of the following best explains their findings?
B
lysosome
(deacidified)
С
lysosome
(acidified)
B-coronavirus
normal
biosynthetic
pathway
egress via
lysosomal
trafficking
SARS-CoV-2 inhibits lysosomes of its host cells by decreasing the pH within them.
SARS-CoV-2 activates lysosomes of its host cells by decreasing the pH within them.
SARS-CoV-2 activates lysosomes of its host cells by increasing the pH within them.
D SARS-CoV-2 inhibits lysosomes of its host cells by increasing the pH within them.
Syn5 is a virus that infects photosynthetic bacteria belonging to the genus Synechococcus. The Syn5 virion is icosahedral (660 Å in diameter) with a short tail and an appendage called a horn. The horn is located on a vertex directly opposite the tail. Syn5 follows the typical five steps observed for most viruses when they multiply, and progeny viruses are released when the host lyses. The assembly of Syn5 virions involves several proteins, including capsid proteins, scaffolding proteins, a portal protein, a terminase, tail proteins, and horn proteins. To better understand the assembly of Syn5 virions, scientists used a type of microscopy called Zernike phase contrast electron cryotomography. This type of microscopy improves the contrast typically seen for conventional cryotomography. In their studies, the scientists observed several different developing virus particles in infected cells. The particles were: (1) 660 Å icosahedron containing DNA and having a tail; (2) 660 Å icosahedron…
List three differences between the structure of HIV and the virus that causes influenza. For one of these differences, explain how the STRUCTURE is key to the FUNCTION of the virus.
Chapter 33 Solutions
Biological Science (6th Edition)
Ch. 33 - 1. What do host cells provide for viruses?
a....Ch. 33 - 2. What does reverse transcriptase do?
Ch. 33 - In the viral replicative cycle, what reaction do...Ch. 33 - 4. What features distinguish the seven major...Ch. 33 - Prob. 5TYUCh. 33 - Prob. 6TYUCh. 33 - Prob. 7TYUCh. 33 - Prob. 8TYUCh. 33 - Prob. 9TYPSSCh. 33 - Which of the following types of viruses would you...
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- Endocytosed enveloped viruses leave endosomal compartments at some point during endosome maturation and fusion with the lysosome. But some types of viruses escape earlier in that process than others. What is one reason why escape might happen at different points?arrow_forwardThe dUTPase enzyme is used by the African swine fever virus to repair its own DNA, as the cells the virus infects in swine do not express the dUTPase protein. Which of the following is a reasonable explanation for the role of the dUTPase in the virus lifecycle? Explain your choice in 25 words or less. The dUTPase is necessary to remove dUTP from the viral genome, as uracil should not be present in DNA The dUTPase is necessary to remove dUTP from the viral genome, as uridine cannot correctly base pair with adenine-containing bases The dUTPase is necessary to remove dUTP from the viral genome, as uridine has the wrong sugar component for building DNA More than one of the above answers is correct None of the above answers is correctarrow_forwardViruses are host-specific, meaning they can only infect specific types of host organisms. For examble, the adenovirus is responsible for the common cold in humans but your dog can't catch a cold from you. Why is this? The proteins on the virus surface can only bind with proteins on the correct host surface. It is an enveloped or non-enveloped virus. The enzymes carried by the virus are compatible with the host. The genome of the virus is made of DNA or RNA.arrow_forward
- What is an envelope? What are spikes (peplomers)? Why do some enveloped viruses have pleomorphic virions? Give two functions spikes might serve in the viral life cycle and the proteins that the influenza virus uses in these processes.arrow_forwardDuring the lysogenic cycle of lambda (1) phage the phage genome is integrated in the host chromosome where it is passed on to daughter cells through binary fission. the phage DNA is copied and accumulates in the cytoplasm. Then a trigger causes capsid proteins to be made and phages are assembled. the product of one prophage gene is made and it activates most of the other prophage genes. the viral genes immediately turn the host cell into a lambda-producing factory. Then the host lyses. 0000arrow_forwardModerna and Pfizer vaccines for COVID-19 use mRNA to the Spike protein combined with lipids. Which of the following is/are advantages of this type of vaccine compared to an inactivated virus vaccine? Select ALL correct answers. a) The vaccine is more stable for transport. b) The vaccine does not contain the virus so it cannot give you COVID-19. c) The vaccine can be rapidly produced in a slightly different form to protect from variants of SARS-CoV-2. d) The vaccine does not need a booster.arrow_forward
- a typical eukarytic cell has a diameter of 50 microns while a corona virus particles has a diameter of 100 nanometers. how many virus particles could be packed into the volum of the typical eurkaryotic cell? (assume the cell and the virus are spherical - V = 4/3 π R^3 and that the particles can use 100% of the space in the cell)arrow_forwardThe viral genome needs to get to the nucleus for the virus that replicates in the nucleus. In other words, the viral nucleocapsid has to overcome two barriers (i.e., plasma membrane and nuclear membrane). Compare and contrast the mechanisms by which the viruses penetrate the two membranes.arrow_forwardSome retroviruses that have a wide host range have been developed for use in treatment of diseases or syndromes. These viruses do not result in a productive infection because they lack critical genes for viral replication, but they do carry DNA sequences that allow them to be packaged into infectious particles. Once in the host cell the viral DNA is released and integrates into the cell's genome. The advantage to this strategy is that the delivery of the DNA is very efficient. What is one possible problem of using a virus that can integrate into the human nuclear genome? Multiple Choice The virus carries genes that will interfere with host cell activities. The viral DNA sequences could still cause a disease. Since the viral DNA sequences no longer contain essential genes for viral replication the host cell may not be able to replicate either. The integration could disrupt an essential gene or genes.arrow_forward
- An antimicrobial drug binds to the HIV reverse transcriptase enzyme, preventing it from working. Which of the following is true of this drug? It would inhibit early replication steps of some viruses, but not affect normal eukaryotic cell activity. It would directly interfere with translation of some viral proteins and some eukaryotic proteins. It would block assembly/maturation steps of some viruses, and interfere with translation in eukaryotic cells. It would interfere with release of newly formed viruses from a host cell, but not affect eukaryotic cells. It would interfere with protein synthesis in bacteria, but not affect eukaryotic ribosomes. It would interfere with mRNA transcription in bacteria and viruses, but not affect eukaryotic transcription.arrow_forwardTat and Rev proteins are required for HIV replication. What are their roles and why are they essential to the virus?arrow_forwardcan someone explain this the lie cycle of influenza repplicationarrow_forward
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