Biological Science (6th Edition)
Biological Science (6th Edition)
6th Edition
ISBN: 9780321976499
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Emily Taylor, Greg Podgorski, Jeff Carmichael
Publisher: PEARSON
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Chapter 33, Problem 13PIAT
Summary Introduction

To review:

The differences in the uncoating step of the HIV (human immunodeficiency virus) and influenza virus.

Introduction:

HIV is the lentivirus that leads to infection and may lead to AIDS (acquired immunodeficiency syndrome). Influenza is a respiratory infection commonly known as flu caused by the influenza virus. The three types of flu viruses are influenza A, influenza B, and influenza C.

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Researchers studying the SARS-CoV-2 virus, also known as COVID-19, have found that the virus is able to circumvent its host cell's normal defenses by leaving the cell via its lyso- somes rather than its normal secretory vesicles, as illustrated in the figure below. endoplasmic reticulum nucleus disrupted lysosomal functions Entry and egress of the SARS-CoV-2 virus A Golgi complex Which of the following best explains their findings? B lysosome (deacidified) С lysosome (acidified) B-coronavirus normal biosynthetic pathway egress via lysosomal trafficking SARS-CoV-2 inhibits lysosomes of its host cells by decreasing the pH within them. SARS-CoV-2 activates lysosomes of its host cells by decreasing the pH within them. SARS-CoV-2 activates lysosomes of its host cells by increasing the pH within them. D SARS-CoV-2 inhibits lysosomes of its host cells by increasing the pH within them.
Syn5 is a virus that infects photosynthetic bacteria belonging to the genus Synechococcus. The Syn5 virion is icosahedral (660 Å in diameter) with a short tail and an appendage called a horn. The horn is located on a vertex directly opposite the tail. Syn5 follows the typical five steps observed for most viruses when they multiply, and progeny viruses are released when the host lyses. The assembly of Syn5 virions involves several proteins, including capsid proteins, scaffolding proteins, a portal protein, a terminase, tail proteins, and horn proteins. To better understand the assembly of Syn5 virions, scientists used a type of microscopy called Zernike phase contrast electron cryotomography. This type of microscopy improves the contrast typically seen for conventional cryotomography. In their studies, the scientists observed several different developing virus particles in infected cells. The particles were: (1) 660 Å icosahedron containing DNA and having a tail; (2) 660 Å icosahedron…
List three differences between the structure of HIV and the virus that causes influenza.  For one of these differences, explain how the STRUCTURE is key to the FUNCTION of the virus.
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