Biological Science (6th Edition)
6th Edition
ISBN: 9780321976499
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Emily Taylor, Greg Podgorski, Jeff Carmichael
Publisher: PEARSON
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Textbook Question
Chapter 32, Problem 12PIAT
CAUTION How is the opossum related to you?
a. An opossum is an animal, but I am a human.
b. An opossum is a mammal, but I am a human.
c. An opossum is a marsupial, but I am a placental mammal.
d. The opossum and I are both placental mammals.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 32 Solutions
Biological Science (6th Edition)
Ch. 32 - True or false? Both echinoderms and vertebrates...Ch. 32 - 2. What trait(s) define(s) the vertebrates?
a....Ch. 32 - The two major lineages that make up the living...Ch. 32 - Most species of hominins are known only from...Ch. 32 - Mammals and birds are both endothermic. Which...Ch. 32 - MODEL Sketch a simple model of a generic chordate...Ch. 32 - 7. There is some evidence that pharyngeal slits...Ch. 32 - MODEL Draw a phylogeny of modem humans that would...Ch. 32 - 9. Consider the evolution of protostomes (Chapter...Ch. 32 - 10. MODEL Genetic diversity in living human...
Ch. 32 - Prob. 11PIATCh. 32 - CAUTION How is the opossum related to you? a. An...Ch. 32 - 13. Gene expression patterns can be used to test...Ch. 32 - 14. PROCESS OF SCIENCE Researchers studied mice...Ch. 32 - 15. The image of the opossum skull shows that the...Ch. 32 - Evolution often results in the co-option of a...
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