EBK BIOLOGY
11th Edition
ISBN: 9780134226453
Author: Byers
Publisher: PEARSON
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Chapter 31, Problem 5FTB
The smallest population of a species that is likely to be able to survive in the long term is called the. When suitable habitat for a given species is split up into areas that are too small to support a large enough population, this is called. One way to maintain large enough populations is to set up core reserves of suitable habitat, connected by ________.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
List substitutions in your diet you could make to improve it based on what you know now about a balanced diet. For instance, if you like to drink soda, you might substitute skim milk or water for some of the soft drinks you consumed. List the item you wish to replace with the new item and what you hope to accomplish with that substitution. Be sure to choose foods you know that you'd enjoy and you consider more "healthful." If you feel your diet is already balanced, describe how you accomplish your balanced intake and when you began eating this way.
Chapter 31 Solutions
EBK BIOLOGY
Ch. 31 - A factor that increases humanity's ecological...Ch. 31 - Prob. 2MCCh. 31 - Prob. 3MCCh. 31 - Prob. 4MCCh. 31 - Which of the following is not true of a population...Ch. 31 - Prob. 1FTBCh. 31 -
2. Products or processes by which functioning...Ch. 31 - Many of the benefits that humans derive from...Ch. 31 - Prob. 4FTBCh. 31 -
5. The smallest population of a species that is...
Ch. 31 -
6. A Native American saying tells us that “We do...Ch. 31 - Prob. 1RQCh. 31 - What is ecological economics? Why is it important?Ch. 31 - Prob. 3RQCh. 31 -
4. What five specific threats to biodiversity are...Ch. 31 - Why are efforts to protect monarch butterflies a...Ch. 31 - List some reasons that the ecological footprints...Ch. 31 -
2. Search for and describe some examples of...
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