Visual Essentials of Anatomy &Physiology
1st Edition
ISBN: 9780321780775
Author: Martini, Frederic
Publisher: Prentice Hall
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Chapter 3.1, Problem 1.8SR
Summary Introduction
To label: The indicated structure on the given cell diagram and describe the function of the structure.
Introduction: Cell is a membrane-bound unit that is present in all living beings and constitutes the basic unit of life. It contains different organelles to carry out different functions. Some cells are specific to their functions.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 3 Solutions
Visual Essentials of Anatomy &Physiology
Ch. 3.1 - A. Describe the immediate cellular destinations of...Ch. 3.1 - Prob. 2LOCh. 3.1 - Prob. 3LOCh. 3.1 - Prob. 4LOCh. 3.1 - Prob. 5LOCh. 3.1 - Prob. 6LOCh. 3.1 - Prob. 7LOCh. 3.1 - Prob. 8LOCh. 3.1 - Prob. 9LOCh. 3.1 - Prob. 1.1R
Ch. 3.1 - Prob. 1.2RCh. 3.1 - Prob. 1.3RCh. 3.1 - Prob. 2.1RCh. 3.1 - Prob. 2.2RCh. 3.1 - Prob. 2.3RCh. 3.1 - Prob. 3.1RCh. 3.1 - Prob. 3.2RCh. 3.1 - Prob. 3.3RCh. 3.1 - Prob. 4.1RCh. 3.1 - Prob. 4.2RCh. 3.1 - Prob. 4.3RCh. 3.1 - Prob. 5.1RCh. 3.1 - Prob. 5.2RCh. 3.1 - Prob. 5.3RCh. 3.1 - Prob. 6.1RCh. 3.1 - Prob. 6.2RCh. 3.1 - Prob. 6.3RCh. 3.1 - Prob. 7.1RCh. 3.1 - Prob. 7.2RCh. 3.1 - Prob. 7.3RCh. 3.1 - Define mitosis, and list its four stages.
Ch. 3.1 - Prob. 8.2RCh. 3.1 - Prob. 8.3RCh. 3.1 - Prob. 9.1RCh. 3.1 - Prob. 9.2RCh. 3.1 - Prob. 9.3RCh. 3.1 - Prob. 1.1SRCh. 3.1 - Prob. 1.2SRCh. 3.1 - Prob. 1.3SRCh. 3.1 - Prob. 1.4SRCh. 3.1 - Prob. 1.5SRCh. 3.1 - Prob. 1.6SRCh. 3.1 - Prob. 1.7SRCh. 3.1 - Prob. 1.8SRCh. 3.1 - Prob. 1.9SRCh. 3.1 - Prob. 2.1SRCh. 3.1 - Matching: Match each lettered term with the most...Ch. 3.1 - Prob. 2.3SRCh. 3.1 - Prob. 2.4SRCh. 3.1 - Prob. 2.5SRCh. 3.1 - Prob. 2.6SRCh. 3.1 - Prob. 2.7SRCh. 3.1 - Prob. 2.8SRCh. 3.1 - Prob. 2.9SRCh. 3.1 - Prob. 2.10SRCh. 3.1 - Prob. 2.11SRCh. 3.1 - Prob. 3SRCh. 3.2 - Explain the process of diffusion, and identify its...Ch. 3.2 - Explain the difference between passive transport...Ch. 3.2 - Prob. 1.1RCh. 3.2 - Prob. 1.2RCh. 3.2 - D. How would a decrease in the oxygen...Ch. 3.2 - Prob. 2.1RCh. 3.2 - Prob. 2.2RCh. 3.2 - Prob. 2.3RCh. 3.2 - Prob. 1SRCh. 3.2 - Prob. 2.1SRCh. 3.2 - Prob. 2.2SRCh. 3.2 - Prob. 2.3SRCh. 3.2 - Prob. 2.4SRCh. 3.2 - Prob. 2.5SRCh. 3.2 - Prob. 2.6SRCh. 3.3 - Define histology and explain the...Ch. 3.3 - Prob. 2LOCh. 3.3 - Prob. 3LOCh. 3.3 - Prob. 4LOCh. 3.3 - Prob. 5LOCh. 3.3 - Prob. 6LOCh. 3.3 - Prob. 7LOCh. 3.3 - Prob. 8LOCh. 3.3 - Prob. 9LOCh. 3.3 - Prob. 10LOCh. 3.3 - Describe the structure and function of bone.
Ch. 3.3 - Prob. 12LOCh. 3.3 - Prob. 13LOCh. 3.3 - Prob. 1.1RCh. 3.3 - Prob. 1.2RCh. 3.3 - Prob. 1.3RCh. 3.3 - Prob. 2.1RCh. 3.3 - B. Summarize the classification of an epithelium...Ch. 3.3 - Prob. 2.3RCh. 3.3 - A. Identify the various types of epithelial...Ch. 3.3 - Prob. 3.2RCh. 3.3 - Prob. 3.3RCh. 3.3 - Prob. 4.1RCh. 3.3 - Prob. 4.2RCh. 3.3 - Prob. 4.3RCh. 3.3 - Prob. 5.1RCh. 3.3 - Prob. 5.2RCh. 3.3 - Prob. 5.3RCh. 3.3 - A. Describe the appearance of simple columnar...Ch. 3.3 - Prob. 6.2RCh. 3.3 - Prob. 6.3RCh. 3.3 - Prob. 7.1RCh. 3.3 - Prob. 7.2RCh. 3.3 - Prob. 7.3RCh. 3.3 - Prob. 8.1RCh. 3.3 - Prob. 8.2RCh. 3.3 - Prob. 8.3RCh. 3.3 - Prob. 9.1RCh. 3.3 - Prob. 9.2RCh. 3.3 - Prob. 9.3RCh. 3.3 - Prob. 10.1RCh. 3.3 - Prob. 10.2RCh. 3.3 - Prob. 10.3RCh. 3.3 - Prob. 11.1RCh. 3.3 - Prob. 11.2RCh. 3.3 - Prob. 11.3RCh. 3.3 - Prob. 12.1RCh. 3.3 - Prob. 12.2RCh. 3.3 - Prob. 12.3RCh. 3.3 - Prob. 13.1RCh. 3.3 - Prob. 13.2RCh. 3.3 - Prob. 13.3RCh. 3.3 - Prob. 1SRCh. 3.3 - Prob. 2.1SRCh. 3.3 - Prob. 2.2SRCh. 3.3 - Prob. 2.3SRCh. 3.3 - Prob. 2.4SRCh. 3.3 - Prob. 2.5SRCh. 3.3 - Prob. 2.6SRCh. 3.3 - Prob. 2.7SRCh. 3.3 - Prob. 2.8SRCh. 3.3 - Prob. 2.9SRCh. 3.3 - Prob. 2.10SRCh. 3.3 - Prob. 2.11SRCh. 3.3 - Prob. 2.12SRCh. 3.3 - Prob. 2.13SRCh. 3.3 - Prob. 2.14SRCh. 3.3 - Prob. 2.15SRCh. 3.3 - Prob. 3SRCh. 3 - Prob. 1CRQCh. 3 - Prob. 2CRQCh. 3 - Prob. 3CRQCh. 3 - Prob. 4CRQCh. 3 - Prob. 5CRQ
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