Biological Science (6th Edition)
6th Edition
ISBN: 9780321976499
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Emily Taylor, Greg Podgorski, Jeff Carmichael
Publisher: PEARSON
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Chapter 30, Problem 9TYPSS
Suppose that a gene originally identified in nematodes (round-worms) is found to be homologous with a gene that can cause developmental abnormalities in humans. Would it be possible to study this same gene in fruit flies? Explain.
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Here are schematic diagrams of mutant Drosophila larvae.
The left side of each pair shows a wild-type larva, with gray boxes showing the sections that are missing in the mutant larva. Which type of gene is defective in each larva: a gap gene, a pair-rule gene, or a segment-polarity gene?
In comparison to experimental results from the genetic manipulation of an invertebrate model, what pathologic outcome(s) would suggest that multiple homologs of a disease gene are present in humans?
a. Missing the essential gene homolog that is lethal in fruit flies is also lethal in human infants.
b. Different homologs of the essential gene are each expressed in different human organs, and mutations in these duplicated genes cause organ-specific diseases.
c. Different homologs of the essential gene are each expressed in different stages of early child development, and mutations in each of these duplicated genes cause different diseases.
d. In humans, defects in different homologs of the essential gene cause different loss-of-function diseases due to subfunctionalization.
e. The essential gene is lethal in fruit flies, but there is no disease phenotype exhibited in people.
A graduate student performing studies on mutations in drosophila (fruit flies) discovered a
strain of flies with a silent mutation in the gene controlling the shape of the wings. Further
investigation has shown that this mutation is lethal in flies who are homozygote. Flies that are
homozygote wild type or heterozygote can develop and are able to survive.
What is a silent mutation (in your own words) and propose a hypothesis that could explain
these observations using concepts learned. (a hypothesis is a proposed explanation based on
an observation or observations)
Chapter 30 Solutions
Biological Science (6th Edition)
Ch. 30 - 1. What synapomorphy (shared, derived trait)...Ch. 30 - 2. In a tube-within-a-tube body plan, what is the...Ch. 30 - True or false? Many new major animal body plans...Ch. 30 - Prob. 4TYKCh. 30 - 5. Why is it ecologically significant that animals...Ch. 30 - Prob. 6TYUCh. 30 - 7. CAUTION Evaluate this statement: Animals...Ch. 30 - 8. Which of the following is an example of...Ch. 30 - Suppose that a gene originally identified in...Ch. 30 - Some sea anemones can produce large colonies by...
Ch. 30 - Why did animal phyla appear so suddenly during the...Ch. 30 - Sperling and Knoll’s approach was to compare the...Ch. 30 - 13. Which of the following traits would help the...Ch. 30 - 14. PROCESS OF SCIENCE The researchers analyzed...Ch. 30 - QUANTITATIVE The graph shows a sample of the...Ch. 30 - Sponges lived in low-oxygen oceans before the...
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- Propose a hypothesis that could explain the following observation. A graduate student performing studies on mutations in drosophila (fruit flies) discovered a strain of flies with a silent mutation in the gene controlling the shape of the wings. Further investigation has shown that this mutation is lethal in flies who are homozygote. Flies that are homozygote wild type or heterozygote can develop and are able to survive.arrow_forwardIt seems that developmental genetics boils down to a complex network of gene regulation. Try to draw a structure of this network for Drosophila. How many genes do you think are necessary to complete the developmental network for the fruit fly? How many genes do you think are needed for a network to specify one segment? Do you think it is more difficult to identify genes that are involved in the beginning, middle, or end of this network? Suppose you were trying to identify all of the genes needed for development in a chicken. Knowing what you know about Drosophila development, would you first try to identify genes necessary for early development, or would you begin by identifying genes involved in cell differentiation?arrow_forwardExplain how loss-of-function mutations in the following categories of genes would affect the morphologies of Drosophila larvae: A. Gap genes B. Pair-rule genes C. Segment-polarity genesarrow_forward
- In addition to C. elegans and Drosophila, Zebrafish are also another model organism - and have a spine. We're interested in two phenotypes, a curved spine and a gene that causes skin tumors to form on the fish's skin. We'd like to know if we could use the curved spine as an indicator if a fish may develop tumors (if the genes are linked). We'll assume that each of these traits is controlled by a single gene where: a curved spine is the result of a dominant allele S (and a normal spine is the result of recessive alleless), ⚫ and tumor growth is the result of a recessive allele t (and no tumor growths are a dominant T allele). A testcross is performed with a fish that is heterozygous for both genes and the resulting progeny are given below. TtSs x ttss curved spine & no tumors curved spine & tumors normal spine & no tumors 27 45 normal spine & tumors 30 SUN 50 Are these two genes following Mendelian inheritance patterns? Use Chi-Squared analysis to test them. x2 = (0-6)² 1. X2 value:…arrow_forwardAn undergraduate researcher in your lab is studying mutations affecting the wings of Drosophila melanogaster. She has identified two mutant phenotypes of interest: bent wings (be), which are recessive to the wild-type straight wings (be+), and apterous (ap) mutants (which are wingless). The apallele is recessive to the wild-type allele (ap+), which allows wings to develop. If a homozygous bent-winged fly (which possesses the normal allele of apterous) is crossed with a homozygous wingless fly (which possesses the normal allele of bent wings), what phenotypic ratio would you expect to observe in the F2 generation of this cross? a) Please indicate the ratio, including the genotypes and phenotypes of all phenotypic classes. Phenotype: Genotype(s) corresponding to this phenotype Phenotypic ratio: (Be sure to NAME the classes in the ratio). B) Please NAME and DEFINE the type of gene interaction illustrated in this example.arrow_forwardWhat changes, if any, would you predict would occur in the pigmentation of Drosophila melanogaster with increased global warming? What type of genetic changes would you expect to see? Be as specific as you can.arrow_forward
- Several Drosophila species with unspotted wings are descended from a spotted ancestor. Would you predict the loss of spot formation to entail coding or noncoding changes in pigmentation genes? How would you test which is the case?arrow_forwardFor the first experiment ever on Drosophila mutations. Answer the following questions. a. What is the title of the first published paper explained the experiment and what is the name of the Author? b. What is the first mutation discovered in Drosophila? c. Explain the changes in the Drosophila yellow mutant (Y)compared to wild type.arrow_forwardYou are studying Hox genes in crane flies (Leptotarsus testaceus). The cranefly genome is sequenced, and in craneflies. Using your understanding of Hox genes, design an experiment testing where the homolog of the EVE gene is expressed in cranefly embryos. you have access to this sequence. You are interested in studying the EVE genearrow_forward
- Why are fruit flies considered a model genetic organism? Would humans fit this description?arrow_forwardAnother way to study the role of proteins (e.g., transcription factors) that function in development is to microinject the mRNA that encodes a protein, or the purified protein itself, into an oocyte or embryo, and then determine how this affects the subsequent development of the embryo, larva, and adult. For example, if Bicoid protein is injected into the posterior region of an oocyte, the resulting embryo will develop into a larva that has anterior structures at both ends. Based on your understanding of the function of each developmental gene, what would be the predicted phenotype if the following proteins or mRNAs were injected into normal oocytes? A. Nanos mRNA injected into the anterior end of an oocyte B. Antp protein injected into the posterior end of an embryo C. Toll mRNA injected into the dorsal side of an early embryoarrow_forward) Explain how and why dorsal/ventral polarity will be affected in fly Question 3 (1. embryos carrying the following mutations; also in each case darken in the area of the cells in the cross-sectional view of the fly embryo which are expected to express the paulie gene. D = dorsal; V = ventral. a) a mutation which results in the deletion of the cytoplasmic domain of the Cookie protein. b) A mutation which results in a constitutively active Bombe protein, i.e. the Bombe protein is always in an activated state. c) A mutation which causes the Pickle protein to be retained in the cytoplasm of the embryo.arrow_forward
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