Biology
4th Edition
ISBN: 9781259188121
Author: Peter Stiling, Robert Brooker, Linda Graham, Eric Widmaier
Publisher: McGraw-Hill Education
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Chapter 30, Problem 3CQ
Core Concept: Structure and Function Compare the structures of an apple flower and a sunflower, explaining how they relate to differences in pollination and seed dispersal.
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Select a diet and give a summary of the main components. Do a web search of the diet and choose one link that provides misinformation. Explain why the site itself and/or the information on the site is not credible. This should be a report. This site should be different from U.S News and World Report.
For full credit, you must include the following information and elaborate in detail:
The diet name
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What misinformation is being provided in the other website and how did you determine it was not credible?
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
Chapter 30 Solutions
Biology
Ch. 30.1 - Core Skill: Connections Look ahead to Figure...Ch. 30.1 - Prob. 1CCCh. 30.1 - Prob. 2BCCh. 30.2 - Prob. 1CCCh. 30.2 - What other trait occurs widely among angiosperms...Ch. 30.2 - What advantage does the nonshowy perianth of grass...Ch. 30.2 - CoreSKILL Designing an experiment requires a plan...Ch. 30.2 - Prob. 2EQCh. 30.3 - Prob. 1CCCh. 30.4 - Prob. 1CC
Ch. 30 - What feature(s) must be present for a plant to...Ch. 30 - Prob. 2TYCh. 30 - Prob. 3TYCh. 30 - What similar features do gymnosperms and...Ch. 30 - Prob. 5TYCh. 30 - Prob. 6TYCh. 30 - Prob. 7TYCh. 30 - Prob. 8TYCh. 30 - Prob. 9TYCh. 30 - Prob. 10TYCh. 30 - Make a diagram that shows how plant biologists...Ch. 30 - Explain why fruits such as apples, strawberries,...Ch. 30 - Core Concept: Structure and Function Compare the...Ch. 30 - Prob. 1COQCh. 30 - How would you go about trying to solve what Darwin...
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