LL ORG CHEM
6th Edition
ISBN: 9781264840083
Author: SMITH
Publisher: MCG
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Question
Chapter 3, Problem 56P
Interpretation Introduction
(a)
Interpretation: The product of the reaction of acebutolol with HCl is to be drawn.
Concept introduction: The most basic
Interpretation Introduction
(b)
Interpretation: The solubility of acebutolol and its hydrochloride salt in water is to be discussed.
Concept introduction: The solubility of a compound depends on its interactions with the solvent molecule.
Interpretation Introduction
(c)
Interpretation: The reason as to why acebutolol is marketed as a hydrochloride salt rather than a neutral molecule is to be stated.
Concept introduction: The drug having more solubility is marketed for its maximum utilization.
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Many drugs are sold as their hydrochloride salts (R,NH2* CI), formed by reaction of an amine (R,NH) with HCI.
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acebutolol
a. Draw the product (a hydrochloride salt) formed by reaction of acebutolol with HCI. Acebutolol is a ß blocker used to treat
high blood pressure.
b. Discuss the solubility of acebutolol and its hydrochloride salt in water.
c. Offer a reason as to why the drug is marketed as a hydrochloride salt rather than a neutral amine.
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Chapter 3 Solutions
LL ORG CHEM
Ch. 3.1 - Prob. 1PCh. 3.2 - (a) Classify the carbon atoms in each compound as...Ch. 3.2 - Problem 3.3 Classify a carbon atom by the number...Ch. 3.2 - Classify each alkyl halide and alcohol as , or...Ch. 3.2 - Prob. 5PCh. 3.2 - Prob. 6PCh. 3.2 - Draw the structure of a compound of molecular...Ch. 3.2 - Prob. 8PCh. 3.2 - Prob. 9PCh. 3.2 - Draw the structure of a compound fitting each...
Ch. 3.4 - Predict which compound in each pair has the higher...Ch. 3.4 - Prob. 17PCh. 3.4 - a Label the hydrophobic and hydrophilic portions...Ch. 3.5 - Prob. 21PCh. 3 - 3.29
Identify the functional groups in the...Ch. 3 - Prob. 32PCh. 3 - 3.31 For each alkane: (a) classify each carbon...Ch. 3 - 3.32 Identify the functional groups in each...Ch. 3 - 3.33 Identify each functional group located in the...Ch. 3 - 3.34 (a)Identify the functional groups in...Ch. 3 - Draw seven constitutional isomers with molecular...Ch. 3 - Prob. 38PCh. 3 - Prob. 39PCh. 3 - Prob. 40PCh. 3 - Intramolecular force of attraction are often...Ch. 3 - 3.40 (a) Draw four compounds with molecular...Ch. 3 - 3.41 Rank the compounds in each group in order of...Ch. 3 - Explain why CH3CH2NHCH3 has higher boiling point...Ch. 3 - Prob. 45PCh. 3 - 3.44 Rank the following compounds in order of...Ch. 3 - Prob. 47PCh. 3 - 3.50 Predict the solubility of each of the...Ch. 3 - Prob. 52PCh. 3 - Prob. 53PCh. 3 - 3.53 THC is the active component in marijuana, and...Ch. 3 - Prob. 55PCh. 3 - Prob. 56PCh. 3 - 3.60 Quinapril (trade name Accupril) is a drug...Ch. 3 - 3.61 Answer each question about oxycodone, a...Ch. 3 - Prob. 65PCh. 3 - Prob. 66PCh. 3 - 3.64 Explain why A is less water soluble than B,...Ch. 3 - 3.65 Recall from section 1.10B that there is...
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