Chapter 3, Problem 3.34.3C

Explain the HMP shunt pathway and its significance

Explain why orthostatic (postural) hypotension may occurwith vasodilator drugs.

A drug has been developed for oral administration as a rapidly dissolving capsule. This drug is also available as an intravenous formulation. Pharmacokinetic studies with both formulations in a relevant patient population provided the following values for absorption rate constant, clearance, volume of distribution and bioavailability: ka = 1.0 h-1; Cl = 9 L/h; V = 90 L; and F = 0.8. Calculate the drug concentration (in the blood) 8 h after a 1000 mg dose is administered orally.

If the rapid infusion of Drug C is 15mg/min over first 10 minutes, how many millilitres from Drug C IV ampule (available as 2mL 100 mg/mL) should be placed in the 100-mL bag?

Enumerate the etiological causes of hemodynamic disorders Explain the pathogenesis and clinical significance of each type of hemodynamic disorders.

Explain in detail why Microsytic anemia is caused by Iron deficency.   Give reasons alongside exmaples

critically analyse in detail the diffrences and similarities of iron deffiency and thalassemia in regards ot microsytic and macrosytic anemia.

It is not usually necessary to assess arterial blood gases when diagnosing and treating asthma. However, this information can sometimes be useful in severe asthma attacks. Suppose that a patient had a PO2 of 60mm hg and a PCo2 of 30mm hg when the patient first went to the emergency room. Explain how that could happen.

3. 10 bme ons Explain the relationship between flow, pressure and resistance in blood vessels, and the factors that affect the amount of resistance. a. Define flow (F), blood pressure (AP), and resistance (R or PR) b. State and apply the general mathematical relationship between flow, blood pressure and resistance. Explain how the body increases and decreases blood flow.