FUNDAMENTALS OF ANATOMY AND PHYSIOLOGY
11th Edition
ISBN: 2818440070938
Author: Martini
Publisher: PEARSON C
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Chapter 3, Problem 20RQ
Suppose that a DNA segment has the following
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 3 Solutions
FUNDAMENTALS OF ANATOMY AND PHYSIOLOGY
Ch. 3 - List the general functions of the plasma membrane.Ch. 3 - Identify the components of the plasma membrane...Ch. 3 - Which component of the plasma membrane is...Ch. 3 - Which type of integral protein allows water, ions,...Ch. 3 - Prob. 5CPCh. 3 - What are the major differences between cytosol and...Ch. 3 - Prob. 7CPCh. 3 - Prob. 8CPCh. 3 - Explain why certain cells in the ovaries and...Ch. 3 - What does the presence of many mitochondria imply...
Ch. 3 - Describe the contents and structure of the...Ch. 3 - What is a gene?Ch. 3 - Define gene activation.Ch. 3 - Describe transcription and translation.Ch. 3 - What process would be affected by the lack of the...Ch. 3 - What is meant by the term selectively permeable...Ch. 3 - Define diffusion.Ch. 3 - List five factors that influence the diffusion of...Ch. 3 - How would a decrease in the concentration of...Ch. 3 - Define osmosis.Ch. 3 - Some pediatricians recommend using a 10 percent...Ch. 3 - Describe the process of carrier-mediated...Ch. 3 - The concentration of hydrogen ions (H+) in the...Ch. 3 - Describe endocytosis.Ch. 3 - Describe exocytosis.Ch. 3 - What is the process called whereby certain types...Ch. 3 - What is the membrane potential of a cell, and in...Ch. 3 - If the plasma membrane of a cell were freely...Ch. 3 - Give the biological terms for (a) cellular...Ch. 3 - What enzymes must be present for DNA replication...Ch. 3 - Describe interphase, and identify its stages.Ch. 3 - A cell is actively manufacturing enough organelles...Ch. 3 - Define mitosis, and list its four stages.Ch. 3 - What would happen if spindle fibers failed to form...Ch. 3 - Define growth factor, and identify several growth...Ch. 3 - An illness characterized by mutations that disrupt...Ch. 3 - Define metastasis.Ch. 3 - Define cellular differentiation.Ch. 3 - Prob. 1RQCh. 3 - The process that transports solid objects such as...Ch. 3 - Plasma membranes are said to be (a) impermeable,...Ch. 3 - _____ ion concentration is high in extracellular...Ch. 3 - At resting membrane potential, the cytoplasmic...Ch. 3 - The organelle responsible for a variety of...Ch. 3 - The synthesis of a functional polypeptide using...Ch. 3 - Prob. 8RQCh. 3 - The movement of water across a membrane from an...Ch. 3 - Prob. 10RQCh. 3 - List the four basic concepts that make up the cell...Ch. 3 - What are four general functions of the plasma...Ch. 3 - What are the primary functions of membrane...Ch. 3 - By what three major transport mechanisms do...Ch. 3 - List five important factors that influence...Ch. 3 - What are the four major functions of the...Ch. 3 - Diffusion is important in body fluids, because it...Ch. 3 - Microvilli are found (a) mostly in muscle cells,...Ch. 3 - When a cell is placed in a(n) _____ solution, the...Ch. 3 - Suppose that a DNA segment has the following...Ch. 3 - Prob. 21RQCh. 3 - The sodium-potassium exchange pump (a) is an...Ch. 3 - If a cell lacked ribosomes, it would not be able...Ch. 3 - List, in sequence, the phases of the interphase...Ch. 3 - List the stages of mitosis, and briefly describe...Ch. 3 - (a) What is cytokinesis? (b) What is the role of...Ch. 3 - The transport of a certain molecule exhibits the...Ch. 3 - Solutions A and B are separated by a selectively...Ch. 3 - A molecule that blocks the ion channels lining...Ch. 3 - What is the benefit of having some of the cellular...Ch. 3 - List the general functions of the plasma membrane.Ch. 3 - Identify the components of the plasma membrane...
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