WHAT IS LIFE? ACHIEVE ACCESS 1 TERM
5th Edition
ISBN: 9781319360702
Author: PHELAN
Publisher: INTER MAC
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Chapter 3, Problem 11SA
Summary Introduction
To review:
How information is stored in the base sequence of DNA.
Introduction:
DNA consists of
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a) Summarize the Watson & Crick model of DNA as they put forth in their letter to Nature.
b) Draw a picture of Watson and Crick's proposed DNA structure, and include measurements they indicate.
c) Is the model they gave still considered accurate?
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WHAT IS LIFE? ACHIEVE ACCESS 1 TERM
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- a) Give a definition of STRs. b) Must each copy of a chromosome have the same number of repeats? c) How many STRs does the FBI use for identification in a criminal case?arrow_forwardWhat part of the replication process is depicted in the photo you uploaded below? DNA polymerase I and ligase in action:arrow_forwardWhat is the purpose of each of the following steps of the DNA isolation process? Blending Salt Detergent Meat tenderizer Ice-cold isopropanolarrow_forward
- Using the envelope depiction we presented in class, draw out chemical structures for thefollowing oligonucleotides. You can abbreviate the bases as Ade, Cyt, Gua, Thy, Ura. A. d(GACA)B. p(d(TATA))C. GUCUparrow_forwardTerpenesA. Provide a reasonable mechanism for the production of geranyl pyrophosphate from IPP andDMAPPB. How many molecules of IPP and how many molecules of DMAPP would you need to makefarnesyl pyrophosphatearrow_forwardDraw the enol form of Thymine, and show how this tautomer could form a Watson-Crickbase pair with Guanine. If this happened, what would be the consequence?arrow_forward
- Consider the two isoprenoid precursors IPP and DMAPP.A. Which one is more susceptible to SN1 reaction? Explain your answerB. Which is a more likely nucleophile? Explain your answerarrow_forwardDraw the structure of the anti-HIV drug AZT (zidovudine), which stops retro-viral DNAsynthesis. When AZT is taken up by cells, it is converted to AZT triphosphate. Explain how thiscompound could interfere with DNA synthesisarrow_forwardIn the mevalonate pathway, three acetyl-CoA are combined to give a C5 product, IPP.A. Write out a 5-step general acid/general base mechanism to explain how HMG-CoA isformed from 3 acetyl-CoA (Note: we are leaving out some details. The enzyme HMG-CoA actuallyuses its Cys residues to accept acetyl groups from 2 acetyl-CoA, making new thioesters and liberatingCoASH) B. Two NADPH and two H+ are required to form mevalonic acid from HMG-CoA. Circle the Hatoms that came from NADPH, and put a square around any H atoms that came from H+.C. Three ATP are used to convert mevalonic acid to IPP. Explain the role of each ATP moleculearrow_forward
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