ANATOMY+PHYSIOLOGY(LL)-W/CONNECT ACCESS
4th Edition
ISBN: 9781266364051
Author: McKinley
Publisher: MCG
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Chapter 29.5, Problem 18WDYL
What are the actions of CRH, HPL, oxytocin, and prolactin during pregnancy?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 29 Solutions
ANATOMY+PHYSIOLOGY(LL)-W/CONNECT ACCESS
Ch. 29.1 - What distinguishes the pre-embryonic period from...Ch. 29.2 - Prob. 2WDYLCh. 29.2 - Prob. 3WDYLCh. 29.2 - How many cells are present initially in the...Ch. 29.2 - Prob. 5WDYLCh. 29.2 - Prob. 6WDYLCh. 29.2 - Prob. 7WDYLCh. 29.2 - What are the two cell layers of the bilaminar...Ch. 29.2 - Which cell layers give rise to each of the three...Ch. 29.2 - Prob. 10WDYL
Ch. 29.3 - Prob. 11WDYLCh. 29.3 - Prob. 12WDYLCh. 29.3 - Prob. 13WDYLCh. 29.3 - Why is it important for a pregnant woman to...Ch. 29.4 - Prob. 15WDYLCh. 29.5 - Prob. 16WDYLCh. 29.5 - How do estrogen and progesterone act to sustain...Ch. 29.5 - What are the actions of CRH, HPL, oxytocin, and...Ch. 29.5 - Prob. 19WDYLCh. 29.5 - Prob. 20WDYLCh. 29.5 - Prob. 21WDYLCh. 29.5 - Prob. 22WDYLCh. 29.5 - Prob. 23WDYLCh. 29.5 - Prob. 24WDYLCh. 29.5 - Prob. 25WDYLCh. 29.6 - How do progesterone, estrogen, and oxytocin...Ch. 29.6 - Prob. 27WDYLCh. 29.6 - Prob. 28WDYLCh. 29.6 - Prob. 29WDYLCh. 29.6 - Prob. 30WDYLCh. 29.6 - Prob. 31WDYLCh. 29.7 - Prob. 32WDYLCh. 29.7 - Prob. 33WDYLCh. 29.8 - Prob. 34WDYLCh. 29.8 - Prob. 35WDYLCh. 29.8 - How does the positive feedback mechanism in...Ch. 29.8 - Prob. 37WDYLCh. 29.9 - Prob. 38WDYLCh. 29.9 - How does codominant inheritance differ from...Ch. 29.9 - Prob. 40WDYLCh. 29.9 - Prob. 41WDYLCh. 29 - _____ 1. The outer layer of the blastocyst that...Ch. 29 - _____ 2. At about day 3 after fertilization, the...Ch. 29 - During gastrulation, cells from the _____ layer of...Ch. 29 - ______ 4. The cells of the embryoblast...Ch. 29 - _____ 5. Which of the following is not an...Ch. 29 - _____ 6. All of the following cardiovascular...Ch. 29 - _____ 7. After a woman gives birth, what happens...Ch. 29 - _____ 8. Freckles are considered to be a dominant...Ch. 29 - _____ 9. Skin color is a trait that is determined...Ch. 29 - A woman is a carrier for the color-blindness gene,...Ch. 29 - Briefly describe the process of fertilization,...Ch. 29 - List the five regions of the mesoderm, and...Ch. 29 - Explain why teratogens are especially harmful to...Ch. 29 - Describe the differences between the embryonic...Ch. 29 - Prob. 15DYKBCh. 29 - Prob. 16DYKBCh. 29 - Prob. 17DYKBCh. 29 - Describe the various ways by which the mothers...Ch. 29 - Compare and contrast strict dominant-recessive...Ch. 29 - Explain the difference between X-linked recessive...Ch. 29 - Prob. 1CALCh. 29 - Ashley is a 29-year-old pregnant woman who is in...Ch. 29 - Ashley is a 29-year-old pregnant woman who is in...Ch. 29 - Prob. 4CALCh. 29 - Ashley is a 29-year-old pregnant woman who is in...Ch. 29 - Prob. 1CSLCh. 29 - Prob. 2CSLCh. 29 - Prob. 3CSL
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