Degeneration occurs after the age of highest functional efficiency, such as reduced ability to repair damage, increased susceptibility to disease, gradual loss of reserve capacities, and compensation for stress. Unrepaired damage of the DNA is an important factor of senescence. Generally, in a mammalian cell, the DNA undergoes a predictable 10,000 to 100,000 damaging events per day. Particularly, due to the oxidative stress from free radicals produced by the cell’s own metabolism .

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Chapter 29, Problem 9TYR

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Degeneration occurs after the age of highest functional efficiency, such as reduced ability to repair damage, increased susceptibility to disease, gradual loss of reserve capacities, and compensation for stress. Unrepaired damage of the DNA is an important factor of senescence. Generally, in a mammalian cell, the DNA undergoes a predictable 10,000 to 100,000 damaging events per day. Particularly, due to the oxidative stress from free radicals produced by the cell’s own metabolism.

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