ANATOMY & PHYSIOLOGY ACCESS CARD
9th Edition
ISBN: 9781265896843
Author: SALADIN
Publisher: MCG
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Chapter 29, Problem 8BYMV
Summary Introduction
To build your medical vocabulary:
syn-
Meaning of the word element:
Together
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 29 Solutions
ANATOMY & PHYSIOLOGY ACCESS CARD
Ch. 29.1 - Prob. 1BYGOCh. 29.1 - Prob. 2BYGOCh. 29.1 - Prob. 3BYGOCh. 29.1 - Prob. 4BYGOCh. 29.1 - Why sperm must meet an egg near the distal end of...Ch. 29.1 - Prob. 2AYLOCh. 29.1 - Prob. 3AYLOCh. 29.1 - Prob. 4AYLOCh. 29.1 - Events that occur between penetration by a sperm...Ch. 29.1 - The division of pregnancy into three trimesters...
Ch. 29.1 - Duration of the preembryonic stage; the three...Ch. 29.1 - The meaning of cleavage; the term for the...Ch. 29.1 - Prob. 9AYLOCh. 29.1 - Prob. 10AYLOCh. 29.1 - Prob. 11AYLOCh. 29.2 - Prob. 5BYGOCh. 29.2 - Prob. 6BYGOCh. 29.2 - Prob. 7BYGOCh. 29.2 - Prob. 8BYGOCh. 29.2 - Prob. 9BYGOCh. 29.2 - Major events that occur in the embryonic stage and...Ch. 29.2 - Prob. 2AYLOCh. 29.2 - Prob. 3AYLOCh. 29.2 - Prob. 4AYLOCh. 29.2 - Prob. 5AYLOCh. 29.2 - Prob. 6AYLOCh. 29.2 - Prob. 7AYLOCh. 29.2 - Prob. 8AYLOCh. 29.2 - Prob. 9AYLOCh. 29.2 - Prob. 10AYLOCh. 29.2 - Prob. 11AYLOCh. 29.3 - Prob. 10BYGOCh. 29.3 - Prob. 11BYGOCh. 29.3 - Prob. 12BYGOCh. 29.3 - Prob. 1AYLOCh. 29.3 - Prob. 2AYLOCh. 29.3 - Prob. 3AYLOCh. 29.3 - Prob. 4AYLOCh. 29.3 - Prob. 5AYLOCh. 29.3 - Prob. 6AYLOCh. 29.3 - Prob. 7AYLOCh. 29.3 - Prob. 8AYLOCh. 29.3 - Three classes of teratogens, with examples of...Ch. 29.3 - Prob. 10AYLOCh. 29.3 - Nondisjunction and how it gives rise to triplo-X,...Ch. 29.4 - Prob. 13BYGOCh. 29.4 - Prob. 14BYGOCh. 29.4 - Prob. 15BYGOCh. 29.4 - Prob. 16BYGOCh. 29.4 - Prob. 17BYGOCh. 29.4 - Prob. 1AYLOCh. 29.4 - Prob. 2AYLOCh. 29.4 - Senescent changes in the integumentary system;...Ch. 29.4 - Prob. 4AYLOCh. 29.4 - Prob. 5AYLOCh. 29.4 - Prob. 6AYLOCh. 29.4 - Prob. 7AYLOCh. 29.4 - Prob. 8AYLOCh. 29.4 - Prob. 9AYLOCh. 29.4 - Prob. 10AYLOCh. 29.4 - Prob. 11AYLOCh. 29.4 - Prob. 12AYLOCh. 29.4 - Prob. 13AYLOCh. 29.4 - Prob. 14AYLOCh. 29.4 - Prob. 15AYLOCh. 29.4 - Prob. 16AYLOCh. 29.4 - Prob. 17AYLOCh. 29.4 - Prob. 18AYLOCh. 29.4 - Prob. 19AYLOCh. 29 - Prob. 1TYRCh. 29 - Prob. 2TYRCh. 29 - Prob. 3TYRCh. 29 - Prob. 4TYRCh. 29 - Which of these results from aneuploidy? a. Turner...Ch. 29 - Fetal urine accumulates in the ______ and...Ch. 29 - One theory of senescence is that it results from a...Ch. 29 - Prob. 8TYRCh. 29 - Prob. 9TYRCh. 29 - Prob. 10TYRCh. 29 - Prob. 11TYRCh. 29 - Aneuploidy is caused by _____, the failure of two...Ch. 29 - Prob. 13TYRCh. 29 - Prob. 14TYRCh. 29 - Prob. 15TYRCh. 29 - Prob. 16TYRCh. 29 - Prob. 17TYRCh. 29 - Prob. 18TYRCh. 29 - Prob. 19TYRCh. 29 - Prob. 20TYRCh. 29 - Prob. 1BYMVCh. 29 - Prob. 2BYMVCh. 29 - Prob. 3BYMVCh. 29 - Prob. 4BYMVCh. 29 - Prob. 5BYMVCh. 29 - Prob. 6BYMVCh. 29 - Prob. 7BYMVCh. 29 - Prob. 8BYMVCh. 29 - Prob. 9BYMVCh. 29 - Prob. 10BYMVCh. 29 - Prob. 1WWTSCh. 29 - Prob. 2WWTSCh. 29 - Prob. 3WWTSCh. 29 - Prob. 4WWTSCh. 29 - Prob. 5WWTSCh. 29 - As the placenta develops, the membranes of its...Ch. 29 - Prob. 7WWTSCh. 29 - Prob. 8WWTSCh. 29 - Prob. 9WWTSCh. 29 - The gradual destruction of telomeres by telomerase...Ch. 29 - Suppose a woman had a mutation resulting in a...Ch. 29 - Prob. 2TYCCh. 29 - Prob. 3TYCCh. 29 - Prob. 4TYCCh. 29 - Only one sperm is needed to fertilize an egg, yet...
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