BIOLOGY: CONCEPTS&INVEST. (LL)
BIOLOGY: CONCEPTS&INVEST. (LL)
5th Edition
ISBN: 9781264706983
Author: Hoefnagels
Publisher: MCG
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Chapter 29, Problem 1WIO
Summary Introduction

To analyze:

The common findings in the patients who receive the bone marrow transplant.

Introduction:

Inside bones, there is a fatty, squishy substance called bone marrow. Hematopoietic stem cells are immature cells found in this bone marrow. When necessary, these stem cells can divide to produce all different kinds of new blood cells. In order to replenish the stem cell population if these cells are killed or injured, a bone marrow transplant may be required.

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a. What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent.  b. What will happen to elimination of the drug in the previous question if the system is saturated? explain and show any math involved
If you wanted to reduce the difference between peak and trough levels that occur with repeated administration of a drug, how would you adjust the dose and dose interval without changing the plateau concentration (plateau is the average of peak and trough levels)? Select your answers for both dose and interval. Hint: It may be helpful to think about this problem using an example such as food. How would you eat if you wanted to maintain very steady hunger/satiety levels without changing your total caloric intake? Options: A. Dose; Increase dose     B. Dose; Decrease dose     C. Dose; Do not change dose     D. Interval; Increase the interval between doses (give the drug less frequently)    E. Interval; Decrease the interval between doses (give the drug more frequently)     F. Interval; Do not change the interval
What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent. Show the math
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