Connect Access for Seeley's Anatomy and Physiology 180 Day Access for LIBERTY UNIVERSITY BIOL 213/215
11th Edition
ISBN: 9781259987304
Author: VanPutte
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 28.3, Problem 9AYP
Locate the boundaries of the perineum and the two triangles within it.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 28 Solutions
Connect Access for Seeley's Anatomy and Physiology 180 Day Access for LIBERTY UNIVERSITY BIOL 213/215
Ch. 28.1 - What are the functions of the reproductive system?Ch. 28.1 - What functions occur in both moles and females,...Ch. 28.2 - Describe the events of meiosis / and meiosis II....Ch. 28.2 - Prob. 4AYPCh. 28.2 - Prob. 5AYPCh. 28.3 - Prob. 6AYPCh. 28.3 - Describe the structure of the scrotum.Ch. 28.3 - Prob. 8AYPCh. 28.3 - Locate the boundaries of the perineum and the two...Ch. 28.3 - Prob. 10AYP
Ch. 28.3 - Whereare the seminiferous tubules and interstitial...Ch. 28.3 - Prob. 12AYPCh. 28.3 - Prob. 13AYPCh. 28.3 - Prob. 14AYPCh. 28.3 - Prob. 15AYPCh. 28.3 - Prob. 16AYPCh. 28.3 - Where, specifically, are sperm cells produced in...Ch. 28.3 - Prob. 18AYPCh. 28.3 - Prob. 19AYPCh. 28.3 - Prob. 20AYPCh. 28.3 - Prob. 21AYPCh. 28.3 - Prob. 22AYPCh. 28.3 - Prob. 23AYPCh. 28.3 - Prob. 24AYPCh. 28.3 - Prob. 25AYPCh. 28.3 - Prob. 26AYPCh. 28.3 - Prob. 27AYPCh. 28.3 - Describe the structures and locations of the glans...Ch. 28.3 - Prob. 29AYPCh. 28.3 - Prob. 30AYPCh. 28.3 - Prob. 31AYPCh. 28.3 - Prob. 32AYPCh. 28.4 - Where are GnRH, LH, FSH, and inhibin produced?...Ch. 28.4 - Prob. 34AYPCh. 28.4 - Explain the regulation of testosterone secretion.Ch. 28.4 - Prob. 36AYPCh. 28.4 - Prob. 37AYPCh. 28.4 - Prob. 38AYPCh. 28.4 - Describe the processes of erection, emission,...Ch. 28.5 - Prob. 40AYPCh. 28.5 - Prob. 41AYPCh. 28.5 - Prob. 42AYPCh. 28.5 - Prob. 43AYPCh. 28.5 - Prob. 44AYPCh. 28.5 - Prob. 45AYPCh. 28.5 - Describe the process of ovulation.Ch. 28.5 - What is the corpus luteum? What happens to it if...Ch. 28.5 - Prob. 48AYPCh. 28.5 - How are the uterine tubes involved in moving the...Ch. 28.5 - Prob. 50AYPCh. 28.5 - Describe the major ligaments holding the uterus in...Ch. 28.5 - Prob. 52AYPCh. 28.5 - Prob. 53AYPCh. 28.5 - Describe the layers of the vaginal wall. What are...Ch. 28.5 - Prob. 55AYPCh. 28.5 - Prob. 56AYPCh. 28.5 - Prob. 57AYPCh. 28.5 - What is the function of the clitoris and bulb of...Ch. 28.5 - Prob. 59AYPCh. 28.5 - Where are the greater and lesser vestibular glands...Ch. 28.5 - Prob. 61AYPCh. 28.5 - Prob. 62AYPCh. 28.5 - Prob. 63AYPCh. 28.5 - Prob. 64AYPCh. 28.6 - Prob. 65AYPCh. 28.6 - Prob. 66AYPCh. 28.6 - Prob. 67AYPCh. 28.6 - What is the length of a typical menstrual cycle?...Ch. 28.6 - On which day does ovulation occur?Ch. 28.6 - Prob. 70AYPCh. 28.6 - Prob. 71AYPCh. 28.6 - Prob. 72AYPCh. 28.6 - Prob. 73AYPCh. 28.6 - Prob. 74AYPCh. 28.6 - Prob. 75AYPCh. 28.6 - Prob. 76AYPCh. 28.6 - Prob. 77AYPCh. 28.6 - Prob. 78AYPCh. 28.6 - Prob. 79AYPCh. 28.6 - Prob. 80AYPCh. 28.6 - Prob. 81AYPCh. 28.6 - Prob. 82AYPCh. 28.6 - Differentiate between menopause and the female...Ch. 28.6 - Prob. 84AYPCh. 28.7 - Prob. 85AYPCh. 28.7 - Prob. 86AYPCh. 28.7 - List the major age-related changes that occur in...Ch. 28.7 - Prob. 88AYPCh. 28 - During meiosis I Homologous chromosomes synapse....Ch. 28 - Prob. 2RACCh. 28 - Prob. 3RACCh. 28 - The site of spermatogenesis in the male is the a....Ch. 28 - Prob. 5RACCh. 28 - Prob. 6RACCh. 28 - Concerning the penis. the membranous urethra...Ch. 28 - Prob. 8RACCh. 28 - Prob. 9RACCh. 28 - Prob. 10RACCh. 28 - In the male, before puberty a. FSH levels are...Ch. 28 - Prob. 12RACCh. 28 - Prob. 13RACCh. 28 - Prob. 14RACCh. 28 - Prob. 15RACCh. 28 - Prob. 16RACCh. 28 - Prob. 17RACCh. 28 - During sexual excitement, which of these...Ch. 28 - Prob. 19RACCh. 28 - Prob. 20RACCh. 28 - Prob. 21RACCh. 28 - Which of these processes or phases in the monthly...Ch. 28 - Prob. 23RACCh. 28 - Prob. 24RACCh. 28 - Prob. 25RACCh. 28 - Prob. 26RACCh. 28 - Prob. 27RACCh. 28 - If an adult male were castrated (testes were...Ch. 28 - Prob. 2CTCh. 28 - Prob. 3CTCh. 28 - Prob. 4CTCh. 28 - If the ovaries are removed from a 20-year-old...Ch. 28 - Prob. 6CTCh. 28 - Prob. 7CTCh. 28 - GnRH can be used to treat some females who want to...Ch. 28 - Prob. 9CTCh. 28 - Prob. 10CTCh. 28 - Prob. 11CT
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