Anatomy and Physiology: An Integrative Approach with Connect Access Card
3rd Edition
ISBN: 9781260254440
Author: Michael McKinley, Valerie O'Loughlin, Theresa Bidle
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 28.1, Problem 3WDL
What are the components of the urogenital triangles in females and males?
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 28 Solutions
Anatomy and Physiology: An Integrative Approach with Connect Access Card
Ch. 28.1 - Prob. 1LOCh. 28.1 - What general components make up the reproductive...Ch. 28.1 - Prob. 2LOCh. 28.1 - What hormones begin to be secreted at puberty, and...Ch. 28.1 - Prob. 3LOCh. 28.1 - What are the components of the urogenital...Ch. 28.2 - Prob. 4LOCh. 28.2 - Prob. 5LOCh. 28.2 - How do sex chromosomes differ from autosomes?Ch. 28.2 - Prob. 5WDL
Ch. 28.2 - Prob. 6LOCh. 28.2 - LEARNING OBJECTIVE
7. Describe events during...Ch. 28.2 - Prob. 8LOCh. 28.2 - Prob. 6WDLCh. 28.2 - Prob. 7WDLCh. 28.2 - Prob. 9LOCh. 28.2 - Prob. 8WDLCh. 28.2 - Prob. 9WDLCh. 28.2 - Prob. 10LOCh. 28.2 - Prob. 10WDLCh. 28.3 - LEARNING OBJECTIVE
11. Describe the gross and...Ch. 28.3 - Prob. 12LOCh. 28.3 - What are the broad ligament, ovarian ligament, and...Ch. 28.3 - How are the primordial, primary, secondary, and...Ch. 28.3 - Prob. 13LOCh. 28.3 - Prob. 14LOCh. 28.3 - Prob. 15LOCh. 28.3 - Prob. 1WDTCh. 28.3 - What follicles are present at birth? What...Ch. 28.3 - Prob. 14WDLCh. 28.3 - What are the three phases of the ovarian cycle,...Ch. 28.3 - Prob. 16LOCh. 28.3 - LEARNING OBJECTIVE
17. List the functions of the...Ch. 28.3 - Prob. 18LOCh. 28.3 - What are the four segments of the uterine tubes,...Ch. 28.3 - Prob. 17WDLCh. 28.3 - Prob. 18WDLCh. 28.3 - Prob. 19LOCh. 28.3 - Prob. 20LOCh. 28.3 - Prob. 21LOCh. 28.3 - Prob. 2WDTCh. 28.3 - What are the three phases of the uterine cycle,...Ch. 28.3 - Compare and contrast the ovarian and uterine...Ch. 28.3 - Prob. 22LOCh. 28.3 - What are the individual components of the female...Ch. 28.3 - Prob. 23LOCh. 28.3 - Prob. 24LOCh. 28.3 - Prob. 22WDLCh. 28.3 - Prob. 23WDLCh. 28.3 - Prob. 25LOCh. 28.3 - Prob. 24WDLCh. 28.4 - LEARNING OBJECTIVE
26. Describe the gross anatomy...Ch. 28.4 - How does the scrotum help regulate the temperature...Ch. 28.4 - LEARNING OBJECTIVE
27. Describe the gross anatomy...Ch. 28.4 - LEARNING OBJECTIVE
28. Explain the process of...Ch. 28.4 - LEARNING OBJECTIVE
29. Compare and contrast...Ch. 28.4 - WHAT DO YOU THINK?
3 If a man’s testes were...Ch. 28.4 - What are the major cell types in the seminiferous...Ch. 28.4 - What hormones are produced by the interstitial...Ch. 28.4 - How does a spermatogonium divide to produce...Ch. 28.4 - Prob. 29WDLCh. 28.4 - Prob. 30LOCh. 28.4 - LEARNING OBJECTIVE
31. Trace the pathway that...Ch. 28.4 - Prob. 30WDLCh. 28.4 - Prob. 32LOCh. 28.4 - Prob. 33LOCh. 28.4 - Prob. 34LOCh. 28.4 - WHAT DO YOU THINK?
4 If a man has a vasectomy, is...Ch. 28.4 - What are the specific functions of the accessory...Ch. 28.4 - How is seminal fluid different from semen?Ch. 28.4 - LEARNING OBJECTIVE
35. Describe the structure and...Ch. 28.4 - What are the similarities and differences between...Ch. 28.4 - Prob. 36LOCh. 28.4 - Prob. 37LOCh. 28.4 - Prob. 34WDLCh. 28.4 - Prob. 35WDLCh. 28.5 - Prob. 38LOCh. 28.5 - Prob. 39LOCh. 28.5 - Prob. 36WDLCh. 28.5 - Prob. 40LOCh. 28.5 - Prob. 37WDLCh. 28.5 - Prob. 41LOCh. 28.5 - Prob. 42LOCh. 28.5 - Prob. 38WDLCh. 28.5 - Prob. 39WDLCh. 28.5 - Prob. 43LOCh. 28.5 - Prob. 40WDLCh. 28.5 - Prob. 44LOCh. 28.5 - LEARNING OBJECTIVE
45. List some of the common...Ch. 28.5 - What factors affect the age that menarche first...Ch. 28.5 - Prob. 46LOCh. 28.5 - Prob. 47LOCh. 28.5 - Prob. 42WDLCh. 28 - _____ 1. The female homologue to the glans of the...Ch. 28 - _____ 2. Ovulation occurs due to a dramatic peak...Ch. 28 - _____ 3. Which statement is accurate about the...Ch. 28 - _____ 4. Which structure contains a primary...Ch. 28 - _____ 5. In the male, what cells produce...Ch. 28 - Prob. 6DYBCh. 28 - _____ 7. Spermatogonia divide by mitosis to form a...Ch. 28 - _____ 8. Sperm are stored in the _____, where they...Ch. 28 - _____ 9. Which statement is accurate about the...Ch. 28 - _____ 10. The paramesonephric ducts in the embryo...Ch. 28 - What are some anatomic similarities between the...Ch. 28 - What hormones are associated with the female...Ch. 28 - Do You Know the Basics?
13. Describe how a primary...Ch. 28 - List the uterine wall layers, and describe the...Ch. 28 - Compare and contrast the ovarian cycle phases and...Ch. 28 - Describe the relationship among the hypothalamus,...Ch. 28 - What is the function of sustentacular cells in the...Ch. 28 - Describe the process of spermatogenesis, including...Ch. 28 - How do erection and ejaculation occur in the male?Ch. 28 - What structures are formed from the...Ch. 28 - Prob. 1CALCh. 28 - Prob. 2CALCh. 28 - The physician reviews Luisas and Victors blood...Ch. 28 - Prob. 4CALCh. 28 - Prob. 5CALCh. 28 - Prob. 1CSLCh. 28 - Caitlyn had unprotected sex with her fianc...Ch. 28 - Prob. 3CSL
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