Chapter 28, Problem 7P

Interpretation Introduction

Interpretation:

The reason for drugs inhibiting the P450 enzymes prove fatal when used in combination with other medicines should be determined.

Concept introduction:

Enzymes that are produced from the cytochrome P₄₅₀ genes usually facilitates the synthesis and metabolism of several chemicals and molecules within cells. Common variations in the cytochrome P₄₅₀ genes can influence the role of the enzymes. A drug interaction can be defined as a change in the action of a drug that can be caused by the related administration with a supplement, food, beverage, or another drug.