Biology
11th Edition
ISBN: 9781259188138
Author: Peter H Raven, George B Johnson Professor, Kenneth A. Mason Dr. Ph.D., Jonathan Losos Dr., Susan Singer
Publisher: McGraw-Hill Education
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Chapter 28, Problem 7A
Plants cannot fix nitrogen, yet some plants do NOT need nitrogen from the soil. This is because
a. of a symbiotic association with a bacterium that can fix nitrogen.
b. these plants are the exceptions that can fix nitrogen.
c. they have been infected by a
d. they are able to obtain nitrogen from the air.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 28 Solutions
Biology
Ch. 28 - Prob. 1UCh. 28 - A cell that can use energy from the sun, and CO2...Ch. 28 - Gram-positive (+) and gram-negative () bacteria...Ch. 28 - Which of the following characteristics is unique...Ch. 28 - The horizontal transfer of DNA using a plasmid is...Ch. 28 - The disease tuberculosis is a. caused by a...Ch. 28 - Prokaryotes participate in the global cycling of...Ch. 28 - Which of the following is typically NOT associated...Ch. 28 - The mechanisms of DNA exchange in prokaryotes...Ch. 28 - The cell wall in both gram-positive and...
Ch. 28 - The three domains of life a. represent variations...Ch. 28 - Ulcers and tooth decay do not appear related, but...Ch. 28 - Bacteria lack independent internal membrane...Ch. 28 - Plants cannot fix nitrogen, yet some plants do NOT...Ch. 28 - If a new form of carbon fixation was discovered...Ch. 28 - Prob. 2SCh. 28 - Use of multiple antibiotics is not a bad idea if...Ch. 28 - Soil-based nitrogen-fixing bacteria appear to be...
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Soil Ecology; Author: Prof. Mark Valen;https://www.youtube.com/watch?v=rByV6yvJ-Ho;License: Standard youtube license