ANATOMY AND PHYSIOLOGY
17th Edition
ISBN: 9781630180928
Author: OpenStax
Publisher: OPENSTAX C
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Textbook Question
Chapter 28, Problem 6RQ
Fusion of pronuclei occurs during ________.
- spermatogenesis
- ovulation
- fertilization
- capacitation
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 28 Solutions
ANATOMY AND PHYSIOLOGY
Ch. 28 - View this time-lapse movie...Ch. 28 - Visit this site...Ch. 28 - Sperm and ova are similar in terms of ________....Ch. 28 - Although the male ejaculate contains hundreds of...Ch. 28 - As sperm first reach the oocyte, they will contact...Ch. 28 - Fusion of pronuclei occurs during ________....Ch. 28 - Sperm must first complete ________ to enable the...Ch. 28 - Cleavage produces daughter cells called ________....Ch. 28 - The conceptus, upon reaching the uterus, first...Ch. 28 - The inner cell mass of the blastocyst is destined...
Ch. 28 - Which primary germ layer gave rise to the cells...Ch. 28 - What would happen if the trophoblast did not...Ch. 28 - During what process does the amnion envelop the...Ch. 28 - The placenta is formed from ________. the embryos...Ch. 28 - The foramen ovale causes the fetal circulatory...Ch. 28 - What happens to the urine excreted by the fetus...Ch. 28 - During weeks 9–12 of fetal development,...Ch. 28 - Progesterone secreted by the placenta suppresses...Ch. 28 - Which of the following is a possible culprit of...Ch. 28 - How does the decrease in progesterone at the last...Ch. 28 - Which of these fetal presentations is the easiest...Ch. 28 - Which of these shunts exists between the right and...Ch. 28 - Why is brown fat important? It is the newborns...Ch. 28 - Constriction of umbilical blood vessels during...Ch. 28 - Alveoli are connected to the lactiferous sinuses...Ch. 28 - How is colostrum most important to a newborn? It...Ch. 28 - Mature breast milk ________. has more sodium than...Ch. 28 - Marfan syndrome is inherited in an autosomal...Ch. 28 - In addition to codominance, the ABO blood group...Ch. 28 - Zoe has cystic fibrosis. Which of the following is...Ch. 28 - Darcy and Raul are having difficulty conceiving a...Ch. 28 - Sherrise is a sexually active college student. On...Ch. 28 - Approximately 3 weeks after her last menstrual...Ch. 28 - The Food and Nutrition Board of the Institute of...Ch. 28 - What is the physiological benefit of incorporating...Ch. 28 - Why would a premature infant requite supplemental...Ch. 28 - Devin is 35 weeks pregnant with her first child...Ch. 28 - Janine is 41 weeks pregnant with her first child...Ch. 28 - Describe how the newborns fust breath alters the...Ch. 28 - Newborns are at much higher risk for dehydration...Ch. 28 - Describe the transit of breast milk from...Ch. 28 - A woman who stopped breastfeeding suddenly is...Ch. 28 - Explain why it was essential that Mendel perform...Ch. 28 - How can a female carrier of an X-linked recessive...
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